Evidence map›Paper›PMID 40247675›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

A first report of progressive multifocal leukoencephalopathy in childhood-onset NMOSD.

Pakeeran Siriratnam, Simon Gosling, Maneesh Bhojak, Michael Griffiths, Rachel Kneen, Evangeline Wassmer, Saif Huda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pakeeran SiriratnamDepartment of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.ORCID 0000-0003-4751-2102
Simon GoslingDepartment of Neurology, Birmingham Women and Children's Hospital, Birmingham, UK.
Maneesh BhojakDepartment of Neuroradiology, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Michael GriffithsCentre of Child and Adolescent Health research, The University of Sydney, Camperdown, NSW, Australia.
Rachel KneenDepartment of Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Evangeline WassmerDepartment of Neurology, Birmingham Women and Children's Hospital, Birmingham, UK.
Saif HudaDepartment of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.ORCID 0000-0003-0980-3750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgressive multifocal leukoencephalopathy (PML) has not been reported in pediatric neuromyelitis optica spectrum disorder (NMOSD) and rarely described in children.

objectivesTo report a case of PML in childhood-onset NMOSD.

methodsA single retrospective case report.

resultsNine years after diagnosis of aquaporin-4 antibody positive NMOSD, a 17-year-old boy treated with rituximab presented with painless right visual loss over 6 weeks coinciding with CD19 repopulation. Acute relapse treatment was given but he continued to deteriorate, and JC virus was detected in cerebrospinal fluid confirming PML.

conclusionPML can occur in childhood-onset NMOSD and protracted clinical presentations with unusual radiological features should prompt JCV testing. Balancing effective immunosuppression while mitigating the risks of associated complications in long-term relapsing conditions remains a challenge.

Indexed as

Leukoencephalopathy, Progressive MultifocalNeuromyelitis OpticaAdolescentAquaporin 4HumansJC VirusMaleRituximabAquaporin 4RituximabimmunologyNeuromyelitis optica (NMO)

Identifiers

PMID40247675
PMCPMC12589659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.