Evidence map›Paper›PMID 40247657›Full record

ArticleAdvanced biology2025

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration.

Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuzheng LuBeijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.ORCID https://orcid.org/0009-0002-4321-8141
Yanbo ShanResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Yingjie XiongResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Jianting YeResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Yanbin WuResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Jipeng SongBeijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Yao ZhangBeijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Wancheng LinBeijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Haoye MengResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Wenjing XuDepartment of Orthopedics of the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
Jiang PengResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Qiang LuResearch Institute of Orthopedic Medicine Department, The Fourth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, China.
Lixiang DingBeijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Funding

Beijing Tianjin Hebei Basic Research Cooperation Special Project 22JCZXJC00130Innovative Research Group Project of the National Natural Science Foundation of China 32371517Talent Training Project of Beijing Shijitan Hospital Affiliated to Capital Medical University during the 14th Five Year Plan Period
6 · The paper itself

Abstract

Magnesium phosphate cement (MPC) continues to gain attention in the field of biomedicine. However, its suboptimal mechanical strength and weak biological activity hinder its wider clinical application. Given the excellent biological characteristics of bioglass fiber (BGF), In this study, magnesium phosphate bone cement (BMPC) containing MPC and BGF with different concentrations (0%, 10%, 20%) are fabricated. Called (MPC, 10BMPC, 20BMPC) respectively. BGF-induced mechanical strengthening is verified through physical and chemical performance tests. In vitro experiments showed that BMPC have better osteogenic properties than MPC and can enhance the proliferation and adhesion capacity of human umbilical vein endothelial cells. In vivo experiment, 20BMPC can significantly promote bone regeneration and vascular network formation, and histological analysis further confirmed the osteogenic capacity of 20BMPC. Transcriptomic analyses confirmed that the activities of the Notch pathway and Hif1 pathway are upregulated in the 20BMPC group, reflecting the strong interconnection between osteogenesis and angiogenesis. 20BMPC, which have the highest BGF content, showed the best performance among all the tested materials. This study showed that BGF improved the mechanical strength of bone cement and enhanced its osteogenic and angiogenic abilities. Therefore, 20BMPC can be used as a new bone repair material.

Indexed as

Bone CementsBone RegenerationGlassMagnesium CompoundsNeovascularization, PhysiologicPhosphatesAnimalsCell ProliferationCeramicsHumansHuman Umbilical Vein Endothelial CellsMiceOsteogenesisBioglassBone CementsfiberglassMagnesium Compoundsmagnesium phosphatePhosphatesbioactive glassbone cementfibermagnesium phosphate

Identifiers

PMID40247657
PMCPMC12365737

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.