Evidence map›Paper›PMID 40247608›Full record

ArticleJournal of neurophysiology2025

Higher hyperpolarization-activated current in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of fragile X mice.

Lauren T Hewitt, Alyssa M Marron, Darrin H Brager

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren T HewittDepartment of Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States.
Alyssa M MarronDepartment of Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States.
Darrin H BragerDepartment of Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0002-3736-0515

Funding

Investigating mechanisms underlying impaired social and spatial cognition in rodent models of Fragile X syndromeR01MH131317 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2022 to 2025
$3.0M
Hippocampal channelopathies in Fragile X SyndromeR01MH100510 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H · 2015 to 2019
$1.9M
Physiological mechanisms underlying disrupted hippocampal function in Fragile X syndromeR56MH125655 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H, COLGIN, LAURA L · 2021 to 2022
$1.2M
Hippocampal channelopathies in Fragile X SyndromeR56MH100510 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BRAGER, DARRIN H · 2020 to 2020
$441k
HHS | National Institutes of Health (NIH) MH100510HHS | National Institutes of Health (NIH) MH131317NIMH NIH HHS R01 MH100510NIMH NIH HHS R01 MH131317NIMH NIH HHS R56 MH100510NIMH NIH HHS R56 MH125655NSF | National Science Foundation Graduate Research Fellowship Program (GRFP)
6 · The paper itself

Abstract

Fragile X syndrome is the most common inherited form of intellectual disability and the leading monogenetic cause of autism. Studies in mouse models of autism spectrum disorders, including the

Indexed as

CA1 Region, HippocampalFragile X SyndromeHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsAction PotentialsAnimalsFragile X Messenger Ribonucleoprotein 1MaleMiceMice, Inbred C57BLMice, KnockoutFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Hyperpolarization-Activated Cyclic Nucleotide-Gated Channelscurrent clampFMRPhippocampusintrinsic excitabilityvoltage clamp

Identifiers

PMID40247608
PMCPMC12160041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.