ArticleEuropean journal of medical research2025
Prognostic role of minimum heart rate in elderly heart failure patients with hypertensive heart disease: an analysis of MIMIC-IV database.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart rate has been documented as a predictive factor in heart failure. However, its prognostic role in specific heart failure patients is diverse and not comprehensively identified.
methodsA retrospective cohort study was conducted based on the MIMIC-IV database. 2476 elderly (≥ 60 years old) patients with heart failure and hypertensive heart disease were recruited. The participants were divided into a low minimum heart rate (MHR) (< 60 bpm) group and a high MHR (≥ 60 bpm) group. Multivariable Cox proportional hazards regression analysis was implemented to evaluate the relationship between the two MHR groups and mortality. The association between prognosis and MHR as a continuous variable was elucidated via the restricted cubic spline model. The association in subgroups was assessed as well.
resultsCompared with high MHR, low MHR was significantly associated with higher 30-day all-cause mortalities (hazard ratio 1.289, 95% confidence interval 1.044 to 1.591, p = 0.018), 90-day all-cause mortality (hazard ratio 1.206, 95% confidence interval 1.007 to 1.444, p = 0.042), and 1-year all-cause mortality (hazard ratio 1.183, 95% confidence interval 1.016 to 1.377, p = 0.03) after adjustment for confounding variables. A U-shaped relationship between outcomes and MHR as a continuous variable was observed, with a nadir at MHR of approximately 50 to 60 bpm. The predictive value of low MHR was significant in women or without comorbidity, but not in men or with comorbidity.
conclusionsWe demonstrated that MHR plays a prognostic role in elderly patients with heart failure and hypertensive heart disease. Low MHR predicts higher all-cause mortality, and the association conforms to a U-shaped pattern. Our findings extend those of previous studies and suggest the potential predictive value of HR in specific heart failure patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.