ArticleParticle and fibre toxicology2025
Fibrotic pulmonary dust foci is an advanced pneumoconiosis lesion in rats induced by titanium dioxide nanoparticles in a 2-year inhalation study.
Article in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles.Nanomaterials (Basel, Switzerland) · 2026Review
- Nanozymes subvert pharmacological conventions: insights from counteracting the placental side effects of TiO₂ nanozymes.Journal of nanobiotechnology · 2026Article
- Biological Safety Analysis of Nanoparticles: Exploring Toxicity, Mechanisms, and Safety Factors for Pharmaceuticals.International journal of nanomedicine · 2026Review
- Mouse pulmonary pathological characteristics induced by Asian-mineral dust transported with Coniothyrium fuckelii at a high altitude of 2,000 meters.Scientific reports · 2025Article
- Differential diagnosis of pneumoconiosis mass shadows and peripheral lung cancer using CT radiomics and the AdaBoost machine learning model.Frontiers in medicine · 2025Article
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Authors and funding
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Funding
Abstract
backgroundWe have previously reported that inhalation exposure to titanium dioxide nanoparticles (TiO
methodsMale and female F344 rats were exposed to 0.5, 2, and 8 mg/m
resultsRats exposed to TiO₂ NPs developed macroscopic white lesions, primarily in the subpleural and hilar regions of the lung, which increased in size and number with exposure concentration. Histologically, two lesion types were identified: (1) Fibrotic Pulmonary Dust Foci (fPDF), characterized by collagen deposition, inflammatory infiltration, and disrupted alveolar epithelial differentiation, and (2) Dust Macules (DM), characterized by macrophage accumulation without significant fibrosis or inflammation. fPDFs, but not DMs, were observed after 13 weeks exposure to TiO₂ NPs, indicating that the DM-type pneumoconiosis lesions required a longer time to develop compared to fPDF-type pneumoconiosis lesions. Histopathological analysis revealed that the DM-type pneumoconiosis lesions that developed in rats exposed to TiO₂ NPs were similar to DM-type pneumoconiosis lesions that develop in humans.
conclusionsInhalation exposure to TiO₂ NPs caused the development of two types of pneumoconiosis lesions in rats with distinct pathological features, fPDFs and DMs. The histopathological similarity of the DM-type pneumoconiosis lesions that developed in rat lung in the present study with the DM-type pneumoconiosis lesions that develop in the human lung adds strong support to the conclusion that humans exposed to airborne TiO₂ NPs are at risk of developing pneumoconiosis.
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