ArticleJournal of nanobiotechnology2025
NIR-programmable 3D-printed shape-memory scaffold with dual-thermal responsiveness for precision bone regeneration and bone tumor management.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Innovative 3D-bioprinted microfibers in calcium phosphate cement platform with Nell-1 to activate nerve-bone axis for synergistic bone, vasculature, and nanofibrous nerve regeneration.Smart molecules : open access · 2026Article
- Comparative In Vitro Evaluation and Osteogenic Mechanisms of Representative Bone Graft Substitutes: Bioactive Glass, Beta-Tricalcium Phosphate, and Deproteinized Bovine Bone.Journal of functional biomaterials · 2026Article
- 3D Printing of Biopolymer-Based Scaffolds for Bone Tissue Engineering: Materials, Fabrication, and Translational Strategies.Molecules (Basel, Switzerland) · 2026Review
- Liposomal multimodal theranostics for bone disorders: from rational responsive delivery and biomimetic strategies to clinical translation.Journal of nanobiotechnology · 2026Review
- Hierarchical biomimetic scaffold with directional guidance and photothermal properties for the repair of critical-sized bone defects.Journal of nanobiotechnology · 2026Article
- Pearl-Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 4D Printing in Regenerative Medicine: Bio-Inspired Applications for Dynamic Tissue Repair.Journal of functional biomaterials · 2026Review
- Porosity optimization confers 3D-printed porous tantalum scaffolds with superior osteogenic capability and biocompatibility over titanium alloys.Journal of orthopaedic surgery and research · 2025Article
- Shape memory hydrogels in tissue engineering: Recent advances and challenges.Bioactive materials · 2025Review
- Sandwich-Layered Structure Nanofiber Conduits Facilitating the Repair of Long-Gap Nerve Defects.ACS omega · 2025Article
- Smart materials: innovative strategies for oral-maxillofacial bone defects repair.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Clinically, intraoperative treatment of bone tumors presents several challenges, including the effective inactivation of tumors and filling of irregular bone defects after tumor removal. In this study, intelligent thermosensitive composite materials with shape-memory properties were constructed using polylactic acid (PLA) and polycaprolactone (PCL), which have excellent biocompatibility and degradability. Additionally, beta-tricalcium phosphate (β-TCP), with its osteogenic properties, and magnesium (Mg) powder, with its photothermal and bone-promoting abilities, were incorporated to improve the osteogenic potential of the composite and enable the material to respond intelligently to near-infrared (NIR) light. Utilizing 3D printing technology, the composite material was prepared into an NIR-responsive shape-memory bone-filling implant that deforms when the scaffold temperature increases to 48 ℃ under NIR laser irradiation. Moreover, at a lower temperature of 42 ℃, mild photothermal therapy promotes macrophage polarization toward the M2 phenotype. This process regulates the secretion of interleukin (IL)-4, IL-10, tumor necrosis factor-α, IL-6, and bone morphogenetic protein (BMP)-2, reducing local inflammation, enhancing the release of pro-healing factors, and improving osteogenesis. Overall, this innovative scaffold is a promising and efficient treatment for filling irregular bone defects after bone tumor surgery.
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Registered trials
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