Observational studyBMC ophthalmology2025
Periorbital necrotizing fasciitis: the Manchester experience.
Observational study in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Periocular necrotizing fasciitis.Frontiers in ophthalmology · 2026Review
- The role of computed tomography scan in assessment of patient with herpes zoster opthalmicus complicated with periorbital necrotizing fasciitis.Surgical neurology international · 2026Article
- Multiple skip incision skin-sparing debridement for perianal necrotizing fasciitis: a retrospective study.World journal of emergency surgery : WJES · 2025Article
- Case Report: Eyelid reconstruction using intact fish skin xenograft following periorbital necrotizing fasciitis.Frontiers in ophthalmology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundTo describe the presentation and management of patients with periorbital necrotizing fasciitis (PONF) through an observational retrospective case series. The clinical notes of twelve consecutive patients managed by the Oculoplastic and Orbital Service and Maxillofacial Service of the Manchester University NHS Foundation Trust between 2018 and 2023 were reviewed. Five of these patients were contactable and gave informed consent for inclusion in the study.
methodsRetrospective review of patient characteristics, risk factors, clinical findings, Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, imaging results, microbiology and histology results, patient management and mortality.
resultsThe majority of the patients were male (n = 3) with a median (IQR) age of 63 (51-71) years. The median (IQR) number of risk factors per patient was 1 (0-1.5). All patients had periorbital swelling at presentation. Median (IQR) LRINEC score was 5 (3-8.5). Group A Streptococcus was isolated from at least one sample (wound swab, tissue sampling, blood culture) in 4 cases. Histology was consistent with PONF in the remaining case. All patients received intravenous antibiotics and had between 1 and 4 surgical debridements. The median (IQR) time from the onset of symptoms to antibiotic treatment was 24 (17-42) hours, and the time of suspected diagnosis to debridement was 4 (2.3-6) hours. The median (IQR) final best recorded visual acuity (BRVA) was 2.0 (0.23-3) logMAR. Three patients developed orbital compartment syndrome; 2 of these had a final BRVA of no perception of light (NPL). The median (IQR) time from the initial surgery to the most recent follow-up was 4 (2.5-42) months. There was no mortality.
conclusionsThis study showed no mortality in PONF due to early antibiotic treatment and surgical debridement. A high index of clinical suspicion for PONF using the LRINEC score and other parameters combined with a low threshold for treatment should be maintained, especially in high-risk groups. Urgent referral to specialist surgical teams to ensure prompt diagnosis and treatment is essential to optimise outcomes in the face of this destructive infection.
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