Evidence map›Paper›PMID 40247184›Full record

ArticleBMC anesthesiology2025

Risk factors for administration of additional neuromuscular block reversal in adults undergoing general anaesthesia: a single centre retrospective case-control study.

Susan R Vishneski, Amit K Saha, Lan C Tran, Rohesh J Fernando, Suneeta K Acharya, Lisa K Lee, Leah B Templeton, Amber K Brooks, L Daniela Smith, T Wesley Templeton

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07758868 (Incidence and Clinical Implications of Residual Neuromuscular Blockade in Patients Planned for Post-Anesthesia Care Unit Admission), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07758868 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Incidence and Clinical Implications of Residual Neuromuscular Blockade in Patients Planned for Post-Anesthesia Care Unit Admission: A Prospective Observational Study

TypeobservationalSponsorAnkara Etlik City HospitalRan2026 to 2026Enrolled160ConditionsTOF
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Susan R VishneskiDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA. svishnes@wakehealth.edu.
Amit K SahaDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
Lan C TranDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
Rohesh J FernandoDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
Suneeta K AcharyaDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
Lisa K LeeDivision of Pediatric Anesthesia, Department of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Leah B TempletonDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
Amber K BrooksDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
L Daniela SmithDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.
T Wesley TempletonDepartment of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157 - 1009, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResidual neuromuscular block continues to be a modifiable risk factor for major postoperative pulmonary complications in adults.

methodsWe performed a large retrospective case-control study at a single center to evaluate both the prevalence and risk factors for clinically significant residual neuromuscular block following reversal with neostigmine.

resultsWe found that clinically significant residual neuromuscular block after reversal with neostigmine is rare, occurring in 3.2% of adults. Risk factors for incomplete reversal with neostigmine following rocuronium administration included: increasing age, ASA physical class status III and IV, a cumulative dose of rocuronium > 0.43 mg•kg

conclusionReversing neuromuscular block with sugammadex in patients at higher risk of incomplete reversal with neostigmine can improve outcomes and reduce costs, especially in cases where qualitative assessment is utilized or when quantitative monitoring is unavailable.

Indexed as

Anesthesia, GeneralNeostigmineNeuromuscular BlockadeNeuromuscular Nondepolarizing AgentsAdultAgedCase-Control StudiesCholinesterase InhibitorsFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsRocuroniumSugammadexCholinesterase InhibitorsNeostigmineNeuromuscular Nondepolarizing AgentsRocuroniumSugammadexAfrican AmericanNeostigmineNeuromuscular blockRocuronium

Identifiers

PMID40247184
PMCPMC12004803

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.