Evidence map›Paper›PMID 40247166›Full record

ReviewBMC infectious diseases2025

Clinical features of HAdV-55 in children with respiratory tract infections: a retrospective case series and literature review.

Lifen Rao, Yueqiang Fu, Ying Lu, Jianhua Wei, Zhongying Yang, Mengling Qi, Chengjun Liu, Yushun Wan, Enmei Liu, Na Zang

Erratum issuedAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lifen Rao *Department of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Yueqiang Fu *Department of Pediatric Intensive Care Unit, Children's Hospital of Chongging Medical University, 400014, Chongqing, China.
Ying LuDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Jianhua WeiDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Zhongying YangDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Mengling QiDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Chengjun LiuDepartment of Pediatric Intensive Care Unit, Children's Hospital of Chongging Medical University, 400014, Chongqing, China.
Yushun WanDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Enmei LiuDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China.
Na ZangDepartment of Respiratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders. China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, 400014, China. zangna1214@126.com.

Funding

National Key Research and Development Program Sub-project YFC2704901National Natural Science Foundation of China 32071123Program for Youth Innovation in Future Medicine, Chongqing Medical University W0178
6 · The paper itself

Abstract

backgroundHuman adenovirus type 55 (HAdV-55) can lead to acute respiratory diseases, significant morbidity, and mortality in children.

methodsHospitalized children diagnosed with HAdV-55 between September 2016 and March 2024 at the Children's Hospital of Chongqing Medical University were retrospectively analyzed. HAdV-55 was detected through polymerase chain reaction and sequencing. Clinical data were collected, including demographic characteristics, clinical manifestations, laboratory findings, imaging results, treatment history, and prognosis. A literature search was conducted using the PubMed database and China National Knowledge Infrastructure from their inception to June 2024. Search terms included "HAdV-55", "HAdV-11a", "adenovirus type 55" and their derivatives. Clinical features were evaluated in conjunction with literature on HAdV-55 infections in children.

resultsFive children with HAdV-55 infection were identified, including one mild, two severe, and two critical. The two critical patients exhibited progressive declines in total blood cell counts, hemoglobin levels and serum albumin levels within a short period. Adenoviral DNA was detected in pleural fluid or serum for them. They received mechanical ventilation, intravenous immunoglobulin, Methylprednisolone, blood transfusions, and antibiotics, while died for acute respiratory distress syndrome (ARDS). The remaining ones recovered and were discharged with good prognosis. A review of 56 cases, including those from this study, revealed that 61.9% (26/42) of infections were classified as severe or critical, with a mortality rate of 16.4% (9/55). Sequelae included bronchiolitis obliterans and bronchiectasis.

conclusionsThe genetic inheritance of HAdV-55 remained stable, with an upward trend of HAdV-55 severe infection among children from 2000 to 2019. Early clinical symptoms of HAdV-55 infection were overlapped with other respiratory viral infections. Rapid declines in blood cell counts, hemoglobin levels and serum albumin, along with dynamic monitoring of viral loads in sterile fluids, may serve as prognostic indicators.

Indexed as

Adenoviruses, HumanAdenovirus Infections, HumanRespiratory Tract InfectionsChildChild, PreschoolChinaFemaleHumansInfantMaleRetrospective StudiesARDSChildrenClinical featuresHAdV-55Infection

Identifiers

PMID40247166
PMCPMC12007208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.