ArticleBMC infectious diseases2025
Inflammatory burden index as a predictor of mortality in septic patients: a retrospective study using the MIMIC-IV database.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Inflammatory burden index (CRP×NLR) is associated with moderate-to-severe endoscopic activity in hospitalized patients with ulcerative colitis: a single-center retrospective study.Crohn's & colitis 360 · 2026Article
- Prognostic Value of the Albumin-to-Prealbumin Ratio in Elderly Patients with Sepsis.Journal of clinical medicine · 2026Article
- The role of prognostic scoring systems in determining mortality and morbidity in patients with Fournier's gangrene.BMC surgery · 2026Article
- Innovative Inflammatory Burden Index for identification of high mortality risk in patients with pulmonary embolism: a large retrospective cohort study.BMJ open respiratory research · 2026Article
- Predictive performance of blood urea nitrogen, cystatin C, and their ratio for in-hospital mortality in sepsis: a Chinese two-center analysis.Open medicine (Warsaw, Poland) · 2026Article
- Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study.Journal of inflammation research · 2026Article
- Associations of inflammatory burden index with the prevalence and mortality of asthma in adults: a population based study.Journal of thoracic disease · 2025Article
- Prognostic value of the inflammatory burden index for disease-specific mortality and intensive care need in Fournier's gangrene.Therapeutic advances in urologyArticle
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Abstract
purposePrevious studies have identified the Inflammatory Burden Index (IBI) as a potential predictor of mortality risk in inflammatory diseases. However, its relationship with mortality rates specifically in septic patients has not been thoroughly investigated. This study aimed to explore the association between IBI and mortality risk in patients with sepsis. PATIENTS AND
methodsWe sourced clinical records of 1,828 septic patients from the Multiparameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV 3.0) dataset, covering the period from 2008 to 2022. The primary endpoint was mortality within 28 days, with secondary endpoints including mortality during intensive care unit (ICU) stays and throughout hospitalization. Patients were categorized into quartiles based on their log-transformed Inflammatory Burden Index (LnIBI) levels. Binary logistic regression was utilized to examine the independent influence of IBI on mortality outcomes, adjusting for confounders. Additionally, the association between IBI and these outcomes was explored using restricted cubic splines and Kaplan-Meier analysis. Further comparison of receiver operating characteristic (ROC) curves was conducted to investigate the predictive performance.
resultsThe study involved 1,828 septic patients, including 1,047 males. The all-cause mortality rates were 17.78% (325/1828) within 28 days, 17.34% (317/1828) during ICU stays, and 18.22% (333/1828) over the course of hospitalization. In the adjusted model, a positive correlation was found between LnIBI and mortality at 28 days (OR 1.093[1.014, 1.179], P = 0.021), during ICU stay (OR 1.106[1.025, 1.195], P = 0.01), and throughout hospitalization (OR 1.1[1.022, 1.187], P = 0.012). The analysis using restricted cubic splines showed a linear correlation between LnIBI and mortality risks. The areas under the curve (AUC) of LnIBI was larger than that of CRP (P < 0.05), and there were no significant differences between LnIBI and Neutrophil counts or Lymphocyte counts (P > 0.05). Kaplan-Meier plots revealed significantly lower survival rates for patients in the highest quartile of LnIBI (P < 0.001).
conclusionElevated IBI values are significantly linked with higher mortality risks within 28 days, during ICU, and throughout the hospitalization period in septic patients.
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