ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sex- and region-dependent neuroinflammation in Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Peripheral and Central miRNA Signatures in Alzheimer's Disease: Tissue-Specific Variability, Sex-Associated Differences, and Implications for Blood-Based Biomarkers.International journal of molecular sciences · 2026Review
- Persistent PirB cleavage drives Golgi-directed trafficking deficits underlying neurodegeneration.Translational neurodegeneration · 2026Article
- Sex differences in the relationship of biomarker change to memory decline in early Alzheimer's disease: an observational cohort study.Biology of sex differences · 2026Observational
- Sex Differences in the Relationship of Biomarker Change to Memory Decline in Early Alzheimer's Disease: an Observational Cohort Study.Research square · 2025Article
- Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Distinct inflammatory profiles in young-onset versus late-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex- and region-dependent neuroinflammation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
introductionDespite known sex differences in immune function and Alzheimer's disease (AD), most studies of neuroinflammation in AD have not been analyzed by sex.
methodsWe performed quantitative in vitro autoradiography of hippocampus, entorhinal cortex, and parietal cortex using [
resultsWe found significant, region-dependent elevations of translocator protein (TSPO) density in AD relative to cognitively normal (CN) and mild cognitive impairment (MCI) in women but not men. Density of tau was increased in AD relative to CN and MCI in both sexes, but only women showed a significant positive correlation between tau and TSPO density. The expression of proinflammatory miRNAs was also significantly increased in AD versus CN or MCI women but not men. DISCUSSION: Women are more susceptible than men to AD/tau-related neuroinflammation, supporting a sex-specific re-examination of the effects of neuroinflammation-targeting interventions in AD. HIGHLIGHTS: We show that neuroinflammation in Alzheimer's disease (AD) is modulated by sex in a region-specific manner. Neuroinflammation was highest in the subiculum and significant only in women. Inflammatory microRNAs (miRNAs) increased in the parietal cortex of women, but not men, with AD. Deposition of tau was highest in the entorhinal cortex and significant in both sexes. Density of tau and TSPO was positively and significantly correlated only in AD women.
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