SynthesisMolecular psychiatry2025
Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis.
Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The relationship between cardiovascular health and common mental disorders among adults aged ≤ 50 years: a systematic review of observational studies.BMC psychiatry · 2026Pooled it
- Prevalence and influencing factors of insomnia in patients with coronary heart disease: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Assessing suicide risk in patients with heart failure: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Association between depressive symptoms and thoracic aortic calcification, and their independent and joint prognostic value for incident atherosclerotic cardiovascular disease in the MESA cohort.The international journal of cardiovascular imaging · 2026Article
- NTPDase2 suppresses hippocampal astrocyte-supplied cholesterol through hydrolyzing eATP in depression.Molecular psychiatry · 2026Article
- The Dangerous Liaison Between Depression and Cardiovascular Disease: A Narrative Review of Epidemiology, Mechanisms, and Clinical Management.Journal of clinical medicine · 2026Review
- Well-being differences and changes in people with somatic and psychiatric disorders or multimorbidities: modelling COVID-19 as a global natural experiment of stress vulnerability.BMJ mental health · 2026Article
- Depression, health anxiety, and five-year mortality after ST-elevation myocardial infarction: the SEMI-CI cohort.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Article
- Chronic stress-induced hypertension: beyond sympathetic activation to autonomic and psychiatric dysregulation.Molecular psychiatry · 2026Article
- Mental Health Service use and Expenditures among Medicare Beneficiaries with Depression, Diabetes and Heart Disease after Cost-sharing Parity.Journal of general internal medicine · 2026Article
- Cardiometabolic Aging Driven by Multi-Organ Crosstalk: Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2026Review
- Prevalence and Determinants of Poor Sleep Quality Among Patients with Established Coronary Heart Disease in Kazakhstan: A Multi-Center Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Association between depression and all-cause, cardiovascular, and non-cardiovascular mortality in the Spanish population: a prospective cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Cardiorenal Syndrome and Depressive Symptoms: Exploring the Mood-Kidney Link With Heart Failure Risk in a Post-hoc Analysis of SPRINT.Kidney medicine · 2026Article
- Article
- Interacting and joint effects of frailty and depressive symptoms in relation to risk of cardio-oncology comorbidity in older adults from three prospective cohorts.BMC geriatrics · 2026Article
- Trajectories of depressive symptoms across pregnancy and the extended postpartum period and future cardiovascular health.medRxiv : the preprint server for health sciences · 2026Article
- Depression, anxiety, and stress symptoms in patients with cardiovascular diseases attending primary health care centers in Western Saudi Arabia: A cross-sectional study.Journal of family medicine and primary care · 2026Article
- Modifiable cardiovascular risk factors in people with polycystic ovarian syndrome (PCOS): Findings from the endocrine and mental health study.American journal of preventive cardiology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Depression is a common psychiatric symptom among patients with cardiovascular disease (CVD), adversely affecting their health. Despite the identification of various contributing factors, the precise mechanisms linking CVD and depression remain elusive. This study conducted a meta-analysis to investigate the association between CVD and depression. Furthermore, a bidirectional Mendelian randomization (MR) analysis was undertaken to clarify the causal relationship between the two conditions. The meta-analysis included 39 studies, encompassing 63,444 patients with CVD, 12,308 of whom were diagnosed with depression. The results revealed a significant association between CVD and depression or anxiety, with an estimated overall prevalence of depression in CVD patients of 20.8%. Subgroup analyses showed that the prevalence of depression in patients with coronary artery disease and heart failure was 19.8% and 24.7%, respectively. According to a random-effects model, depressive symptoms were linked to an increase in unadjusted all-cause mortality compared with non-depressed patients. The MR analysis, employing the inverse-variance weighted method as the primary tool for causality assessment, identified significant associations between various CVD types and depression or anxiety phenotypes. These findings underscore the significant relationship between CVD and depression or anxiety, leading to an elevated risk of all-cause mortality. Moreover, the MR analysis provides the first genetically-informed evidence suggesting that depression plays a critical role in the development and progression of certain CVD subtypes. This emphasizes the need for addressing depressive symptoms in CVD patients to prevent or reduce adverse cardiovascular outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.