ArticleEye (London, England)2025
Outcomes of laser peripheral iridotomy in subgroups of primary angle closure disease eyes according to swept-source optical coherence tomography parameters.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
aimsThis study aimed to examine the impact of laser peripheral iridotomy (LPI) on subgroups of primary angle closure eyes based on swept-source optical coherence tomography (SS-OCT).
methodsSS-OCT was used to image 115 eyes with primary angle-closure disease (PACD) at prior to LPI, 1 week, 4 weeks and 12 weeks after LPI. A hierarchical cluster analysis was conducted to classify PACD eyes into subgroups based on pre-LPI SS-OCT parameters. The primary parameters were then compared after LPI to assess any variations in the outcomes among the identified subgroups. A mixed-effects model was used to evaluate the difference between subgroups and the effect of LPI.
resultsThe hierarchical cluster analysis resulted in the identification of two distinct clusters. Cluster 1 (56 eyes) exhibited larger lens vault, pupil distance, iris volume, iris area, iris thickness 2000, as well as narrower angles (p < 0.05 for all). Cluster 2 (59 eyes) had smaller anterior chamber width and anterior chamber volume (p < 0.05 for all). Following LPI, there was an observed increase in the angle size and a decrease in irido-trabecular contact index (ITCI) in both clusters (p < 0.05 for all). Over a period of 3 months, the cluster 1 exhibited stability in angle size and ITCI, whereas cluster 2 exhibited a gradual decline in angle size and a gradual increase in ITCI (p < 0.05 for all).
conclusionThis study successfully identified two distinct subgroups of PACD eyes based on SS-OCT parameters. Smaller eyes demonstrated a declining response to LPI over a period of 3 months.
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