Evidence map›Paper›PMID 40246963›Full record

ArticleScientific reports2025

In vitro cytotoxicity evaluation of a CMC-SA edible packaging film for migration and safety assessment.

Katerina I Kalliampakou, Evmorfia Athanasopoulou, Aikaterini Spanou, Emmanouil Flemetakis, Theofania Tsironi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katerina I KalliampakouLaboratory of Food Process Engineering, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece.
Evmorfia AthanasopoulouLaboratory of Food Process Engineering, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece.
Aikaterini SpanouLaboratory of Food Process Engineering, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece.
Emmanouil FlemetakisLaboratory of Molecular Biology, Department of Biotechnology, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece.
Theofania TsironiLaboratory of Food Process Engineering, Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera Odos 75, Athens, 11855, Greece. ftsironi@aua.gr.

Funding

Greek Operational Programme for Fisheries 5074718Horizon 2020 872217
6 · The paper itself

Abstract

Edible raw materials have gained attention as sustainable food packaging films, which are often considered a priori safe for human consumption. However, cytotoxicity issues may arise due to the incorporation of additives or modifications of film functionality during the manufacturing process. This study introduces an integrated methodology for the evaluation of potential migration of cytotoxic substances from materials used for the development of conventional and biodegradable food packaging. Carboxymethyl cellulose (CMC) and sodium alginate (SA) were tested as raw materials of an edible (CMC-SA) film, while a low-density-polyethylene (LDPE) film was tested as a conventional material. The CMC-SA film exhibited higher water vapor transmission rate and water vapor permeability, and lower hydrophobicity compared to LDPE (WVTR

Indexed as

AlginatesCarboxymethylcellulose SodiumEdible FilmsFood PackagingCaco-2 CellsCell SurvivalHumansPermeabilityAlginatesCarboxymethylcellulose SodiumCarboxymethyl celluloseCell viabilityEdible filmsFood packagingOxidative stressSodium alginate

Identifiers

PMID40246963
PMCPMC12006323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.