Evidence map›Paper›PMID 40246959›Full record

ArticleCommunications biology2025

Coactosin-like F-actin binding protein (Cotl1) plays a key role in adipocyte differentiation and obesity.

Eunkuk Park, Hyoju Jeon, Kang-Il Oh, Junhwan Jeong, Do-Wan Kim, Hyun-Seok Jin, Seon-Yong Jeong

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eunkuk ParkDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0002-1928-5531
Hyoju JeonDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.
Kang-Il OhDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0001-7787-7394
Junhwan JeongDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.
Do-Wan KimDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0003-4243-8476
Hyun-Seok JinDepartment of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Republic of Korea. jinhs@hoseo.edu.ORCID http://orcid.org/0000-0002-3673-9806
Seon-Yong JeongDepartment of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea. jeongsy@ajou.ac.kr.ORCID http://orcid.org/0000-0002-0625-3530

Funding

Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs) RS-2021-KH113820Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs) RS-2022-KH 130303National Research Foundation of Korea (NRF) 00250485
6 · The paper itself

Abstract

Actin dynamics, mediated by various actin-binding proteins, plays an important role in adipocyte differentiation. We investigated the role of coactosin-like F-actin binding protein (Cotl1) in adipocyte differentiation in vitro and in vivo. Cotl1 expression level was increased during adipocyte differentiation in mouse 3T3-L1 cells and primary cultured adipose-derived stem cells (ADSCs) and during weight gain in adipose tissues. However, Cotl1 deficient in 3T3-L1 and ADSCs inhibited adipocyte differentiation, and Cotl1

Indexed as

AdipocytesAdipogenesisCell DifferentiationMicrofilament ProteinsObesity3T3-L1 CellsAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutPPAR gammaMicrofilament ProteinsPPAR gamma

Identifiers

PMID40246959
PMCPMC12006365

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.