ArticleNature communications2025
Cryo-EM structures of the small-conductance Ca
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Further Investigations on Natural and Synthetic Bis-(1,2,3,4-tetrahydroisoquinoline) Derivatives Interacting with the Apamin-Sensitive Site of Small-Conductance Calcium-Activated Potassium Channels.Molecules (Basel, Switzerland) · 2026Article
- Structural basis for the subtype-selective activation of KStructure (London, England : 1993) · 2026Article
- Small current, big potential: bridging mechanistic insight of the SK channel with translational promise.The Journal of physiology · 2026Article
- Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage.Nature communications · 2026Article
- Structural mechanisms for inhibition and activation of human small-conductance CaNature communications · 2026Article
- Structural basis for the subtype-selectivity of KNature communications · 2026Article
- Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules.eLife · 2025Article
- Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025Article
- Review
- Electrophysiological Mechanisms and Therapeutic Potential of Calcium Channels in Atrial Fibrillation.Reviews in cardiovascular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Young-Woo NamDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-2960-9752
Dohyun ImDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6939-7718
Ana Santa Cruz GarciaDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy and Pharmaceutical Sciences, Boston, MA, USA.
Marios L TringidesDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Hai Minh NguyenDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA, USA.
Yan LiuDivision of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0001-5683-8695
Razan OrfaliDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-0584-4013
Alena RamanishkaDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, USA.ORCID http://orcid.org/0009-0004-5827-8627
Grigore PintilieDepartment of Bioengineering and Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
Chih-Chia SuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-3646-327X
Meng CuiDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy and Pharmaceutical Sciences, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3895-135X
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, Northeastern University School of Pharmacy and Pharmaceutical Sciences, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0576-884X
Edward W YuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-5912-1227
Heike WulffDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0003-4437-5763
K George ChandyLKCMedicine-ICE Collaborative Platform, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Miao ZhangDepartment of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, USA. zhang@chapman.edu.ORCID http://orcid.org/0000-0002-3099-155X
Funding
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MStructural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6MDravet Syndrome Anti-Epileptic Control by Targeting GIRK ChannelsR01NS131467 · NINDS · NORTHEASTERN UNIVERSITY · PI Leigh Daniel Plant · 2023 to 2026
$2.2MDevelopment of SK channel modulators as therapeutic agents for ataxiaR33NS101182 · NINDS · CHAPMAN UNIVERSITY · PI BEZPROZVANNY, ILYA B, ZHANG, MIAO · 2021 to 2021
$723kChannelopathy of KCa2.3 and Zimmermann-Laband syndromeR15NS130420 · NINDS · CHAPMAN UNIVERSITY · PI ZHANG, MIAO · 2024 to 2024
$434kNHLBI NIH HHS R01 HL059949NIGMS NIH HHS U24 GM129541NINDS NIH HHS R01 NS131467NINDS NIH HHS R15 NS130420NINDS NIH HHS R33 NS101182U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R15NS130420U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 4R33NS101182-03
Abstract
Small-conductance Ca
Indexed as
Small-Conductance Calcium-Activated Potassium ChannelsAnimalsCalciumCalmodulinCryoelectron MicroscopyHumansHydrogen BondingModels, MolecularCalciumCalmodulinKCNN2 protein, humanSmall-Conductance Calcium-Activated Potassium Channels
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.