Evidence map›Paper›PMID 40246842›Full record

ArticleNature communications2025

Disease-specific B cell clones are shared between patients with Crohn's disease.

Prasanti Kotagiri, William M Rae, Laura Bergamaschi, Diana Pombal, Ji-Yeun Lee, Nurulamin M Noor, Raoul S Sojwal, Samuel J S Rubin, Lukas W Unger, Sofie H Tolmeijer and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Paradigm Lost.Cancers · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Prasanti KotagiriCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. pk488@cam.ac.uk.ORCID http://orcid.org/0000-0002-9806-4349
William M RaeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Laura BergamaschiCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Diana PombalDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Ji-Yeun LeeDepartment of Pathology, Stanford University, Stanford, CA, 94305, USA.
Nurulamin M NoorDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0003-3426-6408
Raoul S SojwalDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, 94305, USA.
Samuel J S RubinDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-7335-3868
Lukas W UngerCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Sofie H TolmeijerDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Giulia ManferrariDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Rachael J M Bashford-RogersDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UK.
David B BinghamDepartment of Pathology, Stanford University, Stanford, CA, 94305, USA.
Anton StiftDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Stephan RogallaDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, 94305, USA.
John GubatanDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-6037-2883
James C LeeCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Kenneth G C SmithCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3829-4326
Eoin F McKinneyCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-3516-3072
Scott D BoydDepartment of Pathology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-0963-044X
Paul A LyonsCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. pal34@cam.ac.uk.ORCID http://orcid.org/0000-0001-7035-8997

Funding

NIDDK NIH HHS L30 DK126220RCUK | MRC | Medical Research Foundation Programme Grant MR/L019027/1Wellcome Trust CC2219
6 · The paper itself

Abstract

B cells have important functions in gut homeostasis, and dysregulated B cell populations are frequently observed in patients with inflammatory bowel diseases, including both ulcerative colitis (UC) and Crohn's disease (CD). How these B cell perturbations contribute to disease remains largely unknown. Here, we perform deep sequencing of the B cell receptor (BCR) repertoire in four cohorts of patients with CD, together with healthy controls and patients with UC. We identify BCR clones that are shared between patients with CD but not found in healthy individuals nor in patients with UC, indicating CD-associated B cell immune responses. Shared clones are present in the inflamed gut mucosa, draining intestinal lymph nodes and blood, suggesting the presence of common CD-associated antigens that drive B cell responses in CD patients.

Indexed as

B-LymphocytesCrohn DiseaseReceptors, Antigen, B-CellAdultCase-Control StudiesClone CellsColitis, UlcerativeFemaleHigh-Throughput Nucleotide SequencingHumansIntestinal MucosaLymph NodesMaleMiddle AgedReceptors, Antigen, B-Cell

Identifiers

PMID40246842
PMCPMC12006383

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.