Evidence map›Paper›PMID 40246732›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2025

Phenotypic comparison between combined dystonia-parkinsonism and idiopathic adult-onset dystonia.

Sarah Idrissi, Roberto Erro, Marcello Mario Mascia, Assunta Trinchillo, Marcello Esposito, Vittorio Velucci, Roberta Pellicciari, Roberto Ceravolo, Maria Sofia Cotelli, Tommaso Schirinzi and 16 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Predictors of cognitive performance in idiopathic adult-onset dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  3. Multicenter validation of the Italian Pain in Dystonia Scale in idiopathic adult-onset cervical dystonia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sarah IdrissiDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy. idrissi.sarah2589@gmail.com.ORCID 0009-0000-4617-8961
Roberto ErroDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Marcello Mario MasciaNeurology Unit, University Hospital of Cagliari, Cagliari, Italy.
Assunta TrinchilloDepartment of Medical, Motor and Wellness Sciences, University "Parthenope", ICS Maugeri Hermitage, Naples, Italy.
Marcello EspositoClinical Neurophysiology Unit, Cardarelli Hospital, Naples, Italy.
Vittorio VelucciDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Roberta PellicciariDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.
Roberto CeravoloDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Maria Sofia CotelliNeurology Unit, ASST Valcamonica, Esine, Italy.
Tommaso SchirinziDepartment of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Daniela CassanoNeurology Unit, Maria Vittoria Hospital, Turin, Italy.
Anna CastagnaIRCCS Don Carlo Gnocchi Foundation, Milan, Italy.
Maria Concetta AltavistaNeurology Unit, San Filippo Neri Hospital, Rome, Italy.
Carmen TerranovaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Luca MagistrelliParkinson Institute of Milan, ASST G. Pini-CTO, Milan, Italy.
Daniele BelvisiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Gina FerrazzanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Giovanni FabbriniDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Maurizio ZibettiDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
Pierangelo BarberoNeurology Unit, Mauriziano Umberto I Hospital, Turin, Italy.
Antonella MuroniNeurology Unit, University Hospital of Cagliari, Cagliari, Italy.
Antonio PisaniDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Giovanna SquintaniNeurology Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Lucio MarinelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Giovanni DefazioDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical characteristics of dystonia occurring in association with sporadic neurodegenerative parkinsonism have not been systematically explored or compared with those of idiopathic adult-onset dystonia. This study aims to compare demographic and clinical features, including the distribution of dystonia at onset, dystonia-associated features, and the propensity for spread between patients with combined dystonia-parkinsonism and those with idiopathic adult-onset dystonia. Patients were selected from the Italian Dystonia Registry. The study cohort included 130 patients with combined dystonia-parkinsonism and 355 age- and sex-matched patients with isolated adult-onset idiopathic dystonia. The comparison between combined dystonia-parkinsonism and idiopathic dystonia revealed differences in the distribution of dystonia across body regions, with non-task-specific upper limb dystonia, lower limb dystonia, and trunk dystonia occurring more frequently in patients with combined dystonia-parkinsonism. Additionally, this group exhibited a lower frequency of head tremor, eye symptoms associated with blepharospasm, and sensory tricks, alongside a comparable frequency of neck pain related to cervical dystonia and a family history of dystonia or tremor. The clinical presentation of dystonia differs between combined dystonia-parkinsonism and idiopathic dystonia, especially in terms of the body regions affected. These differences underscore the necessity for additional research and suggest underlying pathophysiological disparities between etiological categories that could significantly influence future diagnostics and therapeutic approaches.

Indexed as

DystoniaDystonic DisordersParkinsonian DisordersAdultAgedAge of OnsetFemaleHumansItalyMaleMiddle AgedPhenotypeRegistriesAtypical parkinsonismCombined dystonia-parkinsonismIdiopathic dystoniaParkinson’s diseasePhenotypic comparison

Identifiers

PMID40246732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.