SynthesisThe journal of prevention of Alzheimer's disease2025
Multimorbidity and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.
Synthesis in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Independent and Combined Effects of Obesity and Cardiovascular Diseases on the Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Cohort Studies Involving 8,276,914 Participants.International journal of molecular sciences · 2026Pooled it
- Multimorbidity patterns and cognitive trajectories in older adults: functional, behavioral, and environmental pathways-a longitudinal analysis of CHARLS.Research square · 2026Article
- A comprehensive German claims data analysis of care pathways, risk factors and comorbidities among acetylcholinesterase inhibitor initiators in Alzheimer's disease.Scientific reports · 2026Article
- Predicting All-Cause Mortality Using Two Claims-Based Measures in Medicare Beneficiaries With Dementia.Medical care research and review : MCRR · 2026Article
- Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.The international journal of behavioral nutrition and physical activity · 2026Article
- Accelerating real-world prediction and research in Alzheimer's: The M3AD study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multidomain Predictors of Four-Year Risk for Dementia and Mild Cognitive Impairment Among Community-Dwelling Korean Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- Demographic and clinical influences on emotion prosody recognition.Frontiers in psychology · 2026Article
- Association of cardiometabolic multimorbidity and high-risk lifestyle behaviours with subjective cognitive decline: baseline findings from the China ageing and health survey.Journal of global health · 2025Article
- Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study.Aging clinical and experimental research · 2025Article
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Cardiometabolic multimorbidity in relation to the metabolic score for insulin resistance and creatinine-to-cystatin C ratio in a middle-aged and aged population.Frontiers in endocrinology · 2025Article
- Management of multimorbidity in the midst of cognitive decline through clinical decision-support software.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Red-flagging multimorbidity clusters for Alzheimer's disease risk using explainable machine learning: Evidence from a national emergency department sample.Journal of Alzheimer's disease reportsArticle
- Determinants of Cognitive Change Over 1 Year in Older Adults With Type 1 Diabetes.Diabetes, obesity, and cardiometabolic CAREArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic diseases (e.g., hypertension, diabetes, and heart diseases) have been proposed as marked predictors of incident dementia. However, synthesised evidence on the effect of multimorbidity on dementia is still lacking. We aim to summarise the association between multimorbidity and risk of dementia in longitudinal cohorts.
methodsIn this systematic review and meta-analysis, we conducted a systematic search in PubMed, Web of Science and Embase from inception to Dec 14, 2024, to identify longitudinal cohort studies reporting the association between multimorbidity or multimorbidity patterns and risk of dementia. Information of included studies were extracted by three reviewers (YaZ, YY and YuZ), and the quality assessment was conducted using the Newcastle-Ottawa Scale. The inverse-variance weighted random effects meta-analysis was performed to obtain the pooled hazard ratios (HRs) and 95 % confidence intervals (CIs) for dementia associated with multimorbidity and cardiometabolic multimorbidity (CMM). Cochran's Q test and the I
resultsWe included 17 longitudinal cohort studies (2262,885 middle-aged and older participants) in the systematic review, of which seven were included in meta-analysis. All studies presented moderate to high methodological quality. Meta-analysis showed a positive association between multimorbidity and incident dementia (HR=1.53, 95 % CI=1.12 to 2.09), with substantial heterogeneity (I
conclusionMultimorbidity and CMM pattern were significantly associated with risk of dementia, while the effect of physical and psychological multimorbidity remain inconclusive. Individuals affected by multimorbidity should be prioritised in risk factor modification and dementia prevention. Preventing the development of multimorbidity is also crucial-particularly those who already have one chronic disease-in order to maintain cognitive health.
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