ArticleAJNR. American journal of neuroradiology2025
Simultaneous Multiparametric Estimation of AVM Hemodynamics Using MR Fingerprinting Arterial Spin-Labeling.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeAccurate hemodynamic characterization of cerebral AVMs is critical for treatment-planning, risk-stratification, and posttreatment monitoring but remains challenging due to their abnormal angioarchitecture. MR-fingerprinting (MRF) arterial spin-labeling (ASL) is a novel, noninvasive technique that enables simultaneous quantification of CBF, arterial CBV (aCBV), and bolus-arrival time (BAT) within a single 5-minute scan. This study evaluates the feasibility of MRF-ASL in assessing AVM hemodynamics and compares its sensitivity for AVM detection with CBF measurements obtained using single-delay pseudocontinuous ASL (pCASL). MATERIALS AND
methodsPatients with DSA-confirmed AVMs were scanned on a 3T MRI system. Imaging protocols included MRF-ASL, standard single-delay pCASL, and T2-weighted MRI. MRF-ASL simultaneously-derived CBF, aCBV, and BAT, with CBF estimated using 2 kinetic models: a 1-compartment model, which reflects combined tissue and arterial contributions, and a 2-compartment model, which separates arterial signal from tissue perfusion. Regions of interest were manually drawn over the AVM nidus and contralateral nonaffected tissue. MRF-ASL parameters and pCASL-derived CBF were compared between the AVM nidus and nonaffected tissue. Additionally, linear regression analyses were conducted to examine the relationships among MRF-ASL parameters, single-delay pCASL CBF, and the Spetzler-Martin (SM) grade.
resultsSix patients with AVMs with SM grades ranging from 1 to 5 were included in this study. MRF-ASL parameters revealed significantly elevated CBF
conclusionsIn our preliminary study, MRF-ASL has the potential to provide comprehensive and multiparametric evaluation of AVM hemodynamics, demonstrating superior sensitivity for detecting AVM abnormalities compared with single-delay pCASL. These findings show the feasibility of MRF-ASL as a potentially useful tool for noninvasive characterization and monitoring of AVMs.
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