Evidence map›Paper›PMID 40246442›Full record

ReviewRheumatic diseases clinics of North America2025

Gut and Joint Microbiomes: Implications in Osteoarthritis.

Honey Hendesi, David A Villani, Janne Prawitt, Ann L Gill, Zaid Abdo, Kelly S Santangelo, Lynn Pezzanite, Steven R Gill, Michael J Zuscik

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Rheumatic diseases clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026
    Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Honey HendesiDepartment of Orthopedics, University of Colorado, Anschutz Medical Campus, 12800 East 19th Avenue, RC1N, MS8343, Aurora, CO 80045, USA.
David A VillaniDepartment of Orthopedics, University of Colorado, Anschutz Medical Campus, 12800 East 19th Avenue, RC1N, MS8343, Aurora, CO 80045, USA.
Janne PrawittRousselot BV, Science & Innovation, Meulestedekaai 81, Gent 9000, Belgium.
Ann L GillDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Zaid AbdoDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 200 West Lake Street, Fort Collins, CO 80521, USA.
Kelly S SantangeloDepartment of Microbiology, Immunology, and Pathology, Colorado State University, 200 West Lake Street, Fort Collins, CO 80521, USA.
Lynn PezzaniteAmerican College of Veterinary Surgeons; Department of Clinical Sciences, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Steven R GillDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Michael J ZuscikDepartment of Orthopedics, University of Colorado, Anschutz Medical Campus, 12800 East 19th Avenue, RC1N, MS8343, Aurora, CO 80045, USA. Electronic address: michael.zuscik@cuanschutz.edu.

Funding

Studies on gut microbiome-joint connections in arthritisR01AR078414 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI GILL, STEVEN R., ZUSCIK, MICHAEL J · 2021 to 2025
$3.4M
NIAMS NIH HHS R01 AR078414NIAMS NIH HHS R01AR078414-S1US Department of Defense W81XWH1910807US Department of Defense W81XWH1910808
6 · The paper itself

Abstract

This review summarizes and discusses key recent findings suggesting that microbiomes can play a role in the development and progression of osteoarthritis. Evidence supporting a gut microbiome-joint connection derived from human and animal studies is enumerated and discussed, with particular attention on the microbial and molecular basis for the development of therapeutic interventions that involve targeting the gut. Additionally, clinical data supporting the concept of a living microbiome within a diarthrodial joint are summarized. A discussion of key limitations in the current data and important technical considerations for firmly establishing the existence of a synovial joint microbial community is included.

Indexed as

Gastrointestinal MicrobiomeJointsMicrobiotaOsteoarthritisAnimalsHumansGut microbiomeImmune systemInflammationJoint microbiomeOsteoarthritis

Identifiers

PMID40246442
PMCPMC13492881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.