Upper Respiratory Microbiome in Vasculitis.

A Nikolai von Krusenstiern, Noam A Cohen, Rennie L Rhee

Abstract readReview

In one paragraph

Review in Rheumatic diseases clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A Nikolai von KrusenstiernDepartment of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Noam A CohenDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5th Floor White Building, Philadelphia, PA 19104, USA; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA; Monell Chemical Senses Center, Philadelphia, PA, USA.

Rennie L RheeDivision of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: rennie.rhee@pennmedicine.upenn.edu.

Funding

Molecular and clinical predictors of relapse in ANCA-associated vasculitisR01AR084646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Rennie Rhee · 2024 to 2026

$1.5M

NIAMS NIH HHS R01 AR084646NIAMS NIH HHS R01-AR084646VA BX005432

6 · The paper itself

Abstract

The pathogenesis of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), such as granulomatosis with polyangiitis, is not well understood. These diseases cause significant inflammation in the upper airway. The nares and upper airway are host to many commensal microbes as well as a frequent site of exposure to pathogenic microbes. This review explores the association between upper airway microbial dysregulation and AAV. The role of Staphylococcus aureus colonization as a possible driver of disease is discussed, as well as recent work exploring how fluctuations in the abundance and diversity of commensal microbes are related to vasculitis and risk of flare.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisMicrobiotaRespiratory SystemHumansStaphylococcus aureusANCAGPAMicrobiomeUpper airwayVasculitis

Identifiers

PMID40246437

DOI10.1016/j.rdc.2025.01.001

PMCPMC13093410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.