Evidence map›Paper›PMID 40246361›Full record

ReviewThe Lancet. Child & adolescent health2025

Management of severe acute pulmonary haemorrhage in children.

Alexander I Gipsman, Lauren M C Grant, Joseph C Piccione, Nadir Yehya, Char Witmer, Lisa R Young, Antoinette Wannes Daou, Abhay Srinivasan, Pelton A Phinizy

Abstract readReview
In one paragraph

Review in The Lancet. Child & adolescent health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexander I GipsmanDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: gipsmana@chop.edu.
Lauren M C GrantDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Joseph C PiccioneDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Nadir YehyaDivision of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Char WitmerDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lisa R YoungDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Antoinette Wannes DaouDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abhay SrinivasanDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pelton A PhinizyDivision of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Multidisciplinary Training Program in Pediatric Lung DiseasesT32HL160493 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Sharon Ann McGrath-Morrow, Lisa R. Young · 2022 to 2026
$2.0M
NHLBI NIH HHS T32 HL160493
6 · The paper itself

Abstract

Pulmonary haemorrhage is a potentially life-threatening condition with a variety of causes. Quality clinical trials are insufficient in children, restricting the evidence base to observational data and adult studies. The overall management strategy should address control of symptomatic bleeding, identification of the bleeding source, and treatment of the underlying cause. Flexible bronchoscopy is an important tool used to identify the cause and site of bleeding, do interventional procedures, and directly instil medications to affected areas. Medications to control bleeding include vasoconstrictors, antifibrinolytics, and recombinant factor VIIa. Definitive treatment often requires immunomodulatory medications, bronchial artery embolisation, or surgery. In this Review, we summarise the most recent evidence pertaining to medical, interventional, and surgical treatments of pulmonary haemorrhage in children.

Indexed as

HemorrhageLung DiseasesAcute DiseaseAntifibrinolytic AgentsBronchoscopyChildEmbolization, TherapeuticFactor VIIaHumansVasoconstrictor AgentsAntifibrinolytic AgentsFactor VIIaVasoconstrictor Agents

Identifiers

PMID40246361
PMCPMC12885617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.