Evidence map›Paper›PMID 40246217›Full record

ArticleEnvironmental toxicology and pharmacology2025

Metabolism and genotoxicity of 4,4'-oxydianiline is dependent on N-acetyltransferase 2 genetic polymorphism.

Raul A Salazar-González, James T F Wise, Mark A Doll, David W Hein

Abstract read
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In one paragraph

Article in Environmental toxicology and pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Raul A Salazar-GonzálezDepartment of Pharmacology and Toxicology and UofL Health Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
James T F WiseDepartment of Pharmacology and Toxicology and UofL Health Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Mark A DollDepartment of Pharmacology and Toxicology and UofL Health Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
David W HeinDepartment of Pharmacology and Toxicology and UofL Health Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA. Electronic address: david.hein@louisville.edu.

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI GHARE, SMITA S · 2016 to 2025
$24.1M
Superfund Training CoreP42ES023716 · NIEHS · UNIVERSITY OF LOUISVILLE · PI FORTNER, JOHN · 2017 to 2025
$18.1M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2020 to 2026
$10.0M
UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P42 ES023716NIEHS NIH HHS T32 ES011564NIGMS NIH HHS P20 GM113226
6 · The paper itself

Abstract

4,4'-oxydianiline (ODA) is an environmental aromatic amine reasonably anticipated to be a human carcinogen. We investigated ODA genotoxicity and oxidative stress modified by N-acetyltransferase 2 (NAT2) genetic polymorphism in yeast and DNA repair deficient (UV5) Chinese hamster ovary cells (CHO) expressing human NAT2*4 (rapid acetylator allele) or human NAT2*5B (slow acetylator allele) and in cryopreserved human hepatocytes from rapid, intermediate, or slow NAT2 acetylator genotypes. N-acetylation of ODA was both concentration- and time-dependent and significantly higher in yeast and CHO cells expressing NAT2*4 versus NAT2*5B. ODA-induced DNA damage response and reactive oxygen species (ROS/RNS) were significantly higher, while intracellular reduced glutathione (GSH) and oxidized glutathione (GSSG) ratio or mitochondrial integrity were significantly lower in CHO cells expressing NAT2*4 than NAT2*5B. Dose- and NAT2 phenotype-dependent responses also were observed in human cryopreserved human hepatocytes. Our findings have important implications for precise risk assessments following exposures to ODA and azo dye precursors.

Indexed as

Arylamine N-AcetyltransferaseMutagensAcetylationAnimalsCHO CellsCricetinaeCricetulusDNA DamageGlutathioneHepatocytesHumansOxidative StressPolymorphism, GeneticReactive Oxygen SpeciesSaccharomyces cerevisiaeArylamine N-AcetyltransferaseGlutathioneMutagensNAT2 protein, humanReactive Oxygen Species4,4′-diaminodiphenyl ether4,4’-oxydianilineAcetylator phenotypeGenotoxicityN-acetyltransferase 2Oxidative stress

Identifiers

PMID40246217
PMCPMC12129663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.