Evidence map›Paper›PMID 40245951›Full record

Trial reportThe Journal of allergy and clinical immunology2025

Asthma treatment response modified by fine particulate matter, nitrogen dioxide, and ozone among Black children: A reanalysis of the AsthmaNet Best African American Response to Asthma Drugs trial.

Lizbeth F Gómez, Ellen J Kinnee, Michael T Young, Joel D Kaufman, Anne M Fitzpatrick, Sharmilee M Nyenhuis, Julian Solway, Steven R White, Edward T Naureckas, Wanda Phipatanakul and 8 more

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Reply.The Journal of allergy and clinical immunology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Lizbeth F GómezDepartment of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, Pa. Electronic address: lizbeth.gomez@pennmedicine.upenn.edu.
Ellen J KinneeUniversity Center for Social and Urban Research, University of Pittsburgh, Pittsburgh, Pa.
Michael T YoungDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Wash.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Wash.
Anne M FitzpatrickDepartment of Pediatrics, Emory University, Atlanta, Ga.
Sharmilee M NyenhuisDepartment of Pediatrics-Allergy and Immunology, University of Chicago, Chicago, Ill.
Julian SolwayDepartment of Medicine, Pulmonary and Critical Care, University of Chicago, Chicago, Ill.
Steven R WhiteDepartment of Medicine, Pulmonary and Critical Care, University of Chicago, Chicago, Ill.
Edward T NaureckasDepartment of Medicine, Pulmonary and Critical Care, University of Chicago, Chicago, Ill.
Wanda PhipatanakulDivision of Immunology, Boston Children's Hospital, Boston, Mass.
Michael E WechslerDepartment of Medicine, National Jewish Health, Denver, Colo.
Susan J KunselmanDepartment of Public Health Sciences, Pennsylvania State University, University Park, Pa.
David T MaugerDepartment of Public Health Sciences, Pennsylvania State University, University Park, Pa.
Leslie A McClureCollege of Public Health and Social Justice, Saint Louis University, St Louis, Mo.
Usama BilalDepartment of Epidemiology and Urban Health Collaborative, Drexel University Dornsife School of Public Health, Philadelphia, Pa.
Stephen C LazarusDivision of Pulmonary & Critical Care Medicine, University of California San Francisco, San Francisco, Calif.
Fernando HolguinMedicine-Pulmonary Sciences & Critical Care, University of Colorado School of Medicine, Aurora, Colo.
Jane E CloughertyDepartment of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, Pa.

Funding

Data Coordinating Center for the NHLBI Asthma Network (AsthmaNet)U10HL098115 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2009 to 2015
$57.6M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
AsthmaNet: Brigham and Women's Hospital & Children's Hospital BostonU10HL098102 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, PHIPATANAKUL, WANDA · 2009 to 2015
$5.5M
Clinical Centers for the NHLBI Asthma Network (AsthmaNet)U10HL098075 · NHLBI · NATIONAL JEWISH HEALTH · PI SZEFLER, STANLEY J., WECHSLER, MICHAEL E · 2009 to 2015
$5.1M
AsthmaNet: UW-Madison Clinical and Translational Research CenterU10HL098090 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LEMANSKE, ROBERT F, SORKNESS, CHRISTINE ANNE · 2009 to 2015
$4.8M
UCSF AsthmaNet Clinical CenterU10HL098107 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CABANA, MICHAEL D, LAZARUS, STEPHEN C · 2009 to 2015
$4.8M
AsthmaNet: Phenotypic Influences on Asthma TreatmentsU10HL098177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOLGUIN, FERNANDO, WENZEL, SALLY E · 2009 to 2015
$4.7M
Arizona/Duke Clinical Center for AsthmaNetU10HL098112 · NHLBI · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, MARTINEZ, FERNANDO D · 2009 to 2015
$4.7M
Chicagoland Metropolitan AsthmaNet Consortium (CMAC)U10HL098096 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KRISHNAN, JERRY A., PONGRACIC, JACQUELINE · 2009 to 2015
$4.6M
Washington University AsthmaNetU10HL098098 · NHLBI · WASHINGTON UNIVERSITY · PI BACHARIER, LEONARD B, CASTRO, MARIO · 2009 to 2015
$4.5M
Protein-Oxidized Phospholipid Interactions Determine Epithelial Cell Fate and Asthma Control  R01AI145406 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sally E Wenzel · 2020 to 2026
$2.9M
Validating GIS-based methods to address spatial uncertainty in clinical trialsR01HL114536 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLOUGHERTY, JANE ELLEN, HOLGUIN, FERNANDO · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL114536NHLBI NIH HHS U10 HL098075NHLBI NIH HHS U10 HL098090NHLBI NIH HHS U10 HL098096NHLBI NIH HHS U10 HL098098NHLBI NIH HHS U10 HL098102NHLBI NIH HHS U10 HL098107NHLBI NIH HHS U10 HL098112NHLBI NIH HHS U10 HL098115NHLBI NIH HHS U10 HL098177NIAID NIH HHS R01 AI145406NIEHS NIH HHS P30 ES027792Wellcome Trust
6 · The paper itself

Abstract

backgroundAsthma morbidity significantly affects children of all racial backgrounds; however, Black children experience a greater disease burden than children from other racial groups. Despite the known influence of air pollution on asthma outcomes, its role in the efficacy of asthma treatments remains underexplored.

objectiveWe sought to examine how exposure to particulate matter <2.5 μm (PM

methodsThe trial randomized 224 Black children to 4 asthma treatments consisting of an inhaled corticosteroid (ICS) and long-acting β-agonist (LABA) administered in a randomized crossover fashion. Treatment efficacy was assessed by the frequency of asthma exacerbations, percent predicted FEV

resultsPM

conclusionResidential high NO

Indexed as

Anti-Asthmatic AgentsAsthmaNitrogen DioxideOzoneParticulate MatterAdolescentAdrenal Cortex HormonesAir PollutantsBlack or African AmericanChildChild, PreschoolCross-Over StudiesEnvironmental ExposureFemaleHumansMaleAdrenal Cortex HormonesAir PollutantsAnti-Asthmatic AgentsNitrogen DioxideOzoneParticulate Matterair pollutionAsthmaenvironmental healthICSLABArandomized clinical trial

Identifiers

PMID40245951
PMCPMC12286556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.