ArticleAmerican journal of perinatology2025
Hemolytic Disease of the Fetus and Newborn in an Integrated Health Care System.
Article in American journal of perinatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Health Care Use and Recurrence Rate in Hemolytic Disease of the Fetus and Newborn: Retrospective Cohort Study.JMIR pediatrics and parenting · 2026Article
- Impact of Rh five-antigen-matched transfusion on alloimmunization and clinical outcomes in patients requiring repeated red blood cell transfusions: a prospective randomized controlled study.Frontiers in medicine · 2026Article
- Feasibility of Hemolytic Disease of the Fetus and Newborn Case Ascertainment and Assessing Its Impact on Prenatal and Postnatal Outcomes: Protocol for Observational Studies.JMIR research protocols · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemolytic disease of the fetus and newborn (HDFN) is associated with significant infant morbidity and mortality. Characteristics of pregnancies impacted by HDFN are not well understood. Therefore, this study examines maternal and infant characteristics based on HDFN status in a large, integrated health care system in the United States.This was a population-based, retrospective cohort study of 464,711 pregnancies that received care at Kaiser Permanente Southern California (KPSC) hospitals from January 2008 to June 2022. HDFN cases were ascertained using a validated algorithm of structured and unstructured data elements. HDFN due to ABO alloimmunization alone was excluded. Adjusted odds ratios (aORs) derived from logistic regression were used to describe the association between maternal and infant characteristics and HDFN diagnosis as well as adverse perinatal outcomes. For rare events, Firth's bias-reduced logistic regression was applied.A total of 136 HDFN pregnancies with 138 HDFN births (live births = 137; stillbirth = 1) were observed in the study. Of three twin pregnancies, all but one fetus had an HDFN diagnosis. HDFN diagnosis was associated with a maternal age of ≥35 years (aOR: 1.74; 95% confidence interval [CI]: 1.13-2.67), hypertension (2.07; 0.96-4.50), renal disease (3.43; 1.75-6.70), and multiparity (4.95; 2.73-8.95). Furthermore, HDFN diagnosis was associated with birth at 33 to 34 weeks (aOR: 5.72; 95% CI: 2.78-11.78) and 35 to 36 weeks (3.76; 2.38-5.94), and neonatal jaundice (3.11; 2.20-4.41). Birth weight ≥4,000 g was associated with lower HDFN diagnosis odds than normal weight (2,500-3,999 g; aOR: 0.36; 95% CI: 0.14-0.90). Hispanic race/ethnicity was associated with a lower HDFN diagnosis risk than non-Hispanic White (aOR: 0.63; 95% CI: 0.43-0.93).This study identified clinical and demographic factors linked with HDFN diagnosis, including specific maternal characteristics, medical/obstetrical factors, and neonatal factors, within a large, integrated health care system that can help inform management plans. · Characteristics of HDFN are not well understood.. · This study examined HDFN characteristics in the United States.. · HDFN risk is linked to medical/obstetric factors.. · Increased risk of prematurity associated with HDFN..
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.