Evidence map›Paper›PMID 40245353›Full record

ArticleJournal of the American Chemical Society2025

Chirality-Promoted Chemical Ligation and Reverse Transcription of

Hikari Okita, Keiji Murayama, Hiroyuki Asanuma

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hikari OkitaGraduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.ORCID 0009-0006-0168-5584
Keiji MurayamaGraduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.ORCID 0000-0002-6537-0120
Hiroyuki AsanumaGraduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.ORCID 0000-0001-9903-7847

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The building blocks of current life on Earth are chiral compounds, such as 2'-deoxy-D-ribose of DNA and L-amino acids with homochirality, which play an important role in various biological reactions. We investigated the effect of chirality on the template-directed chemical synthesis of nucleic acids as a model for primitive replication of genetic materials in the absence of enzymes. The efficiency of the template-directed chemical ligation of two

Indexed as

Nucleic AcidsReverse TranscriptionAmino AlcoholsButylene GlycolsDNARNAStereoisomerismAmino AlcoholsButylene GlycolsDNANucleic AcidsRNAthreoninol

Identifiers

PMID40245353
PMCPMC12123609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.