Evidence map›Paper›PMID 40245338›Full record

ArticleJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2025

Advancing Adhesive Strategies for Endodontically Treated Teeth-Part II: Dentin Sealing Before Irrigation Increases Long-Term Microtensile Bond Strength to Coronal Dentin.

Joana A Marques, Rui I Falacho, Gabriela Almeida, Francisco Caramelo, João Miguel Santos, João Rocha, Markus B Blatz, João Carlos Ramos, Paulo J Palma

Abstract read
In one paragraph

Article in Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joana A MarquesInstitute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-5210-6155
Rui I FalachoCenter for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-7099-8871
Gabriela AlmeidaDentistry Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0009-0009-6170-4857
Francisco CarameloCenter for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0002-0015-8604
João Miguel SantosInstitute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0002-2865-9689
João RochaDepartment of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-0417-9402
Markus B BlatzDepartment of Preventive and Restorative Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6341-7047
João Carlos RamosCenter for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-1965-1092
Paulo J PalmaInstitute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-4730-8072

Funding

FCT/MEC (PIDDAC) LA/P/0006/2020FCT/MEC (PIDDAC) UIDB/50011/2020FCT/MEC (PIDDAC) UIDP/50011/2020
6 · The paper itself

Abstract

objectiveTo compare the long-term microtensile bond strength (μTBS) to coronal dentin using pre-endodontic dentin sealing (PEDS) and post-endodontic adhesion (PEA) techniques under various endodontic irrigation protocols. MATERIALS AND

methodsTen study groups (n = 10) were established based on the timing of adhesive application (PEDS versus PEA) and irrigation protocol: distilled water (control), 3% sodium hypochlorite (NaOCl), 3% NaOCl followed by 17% ethylenediaminetetraacetic acid (EDTA), 3% NaOCl followed by 17% EDTA and 2% chlorhexidine, and a mixture of 3% NaOCl and 9% etidronic acid (HEDP). Specimens underwent μTBS testing after a six-month microspecimen aging period. Fracture patterns were analyzed, and adhesive interfaces were assessed using scanning electron microscopy (SEM). Statistical analysis employed a mixed linear regression model with a 5% significance level.

resultsPEDS consistently preserved high bond strength across all irrigation protocols (57.4-59.5 MPa), while PEA groups treated with endodontic irrigants resulted in significantly lower values (33.3-40.8 MPa; p < 0.001). No significant differences were observed within the PEDS groups (p > 0.05). SEM analysis revealed consistent hybrid layers in PEDS and PEA/Control groups, while PEA groups treated with endodontic irrigation solutions showed significant resin-dentin interface variations and interfacial gaps.

conclusionsThe PEDS technique preserved high and consistent μTBS regardless of the irrigation protocol, whereas endodontically irrigated PEA groups exhibited significantly reduced bond strength. PEDS offers a predictable approach to optimizing adhesive performance in endodontic-restorative treatments. CLINICAL SIGNIFICANCE: Integrating PEDS into routine endodontic-restorative workflow is recommended to enhance long-term bond strength to coronal dentin. The PEDS technique ensures consistent adhesive performance regardless of the endodontic irrigation protocol, enhancing restorative predictability and treatment success while preserving tooth structure.

Indexed as

Dental BondingDentinDentin-Bonding AgentsTooth, NonvitalDental Stress AnalysisHumansIn Vitro TechniquesMaterials TestingMicroscopy, Electron, ScanningRoot Canal IrrigantsSodium HypochloriteTensile StrengthTherapeutic IrrigationDentin-Bonding AgentsRoot Canal IrrigantsSodium Hypochloritedentindentin bonding agentsendodonticsmicrotensile bond strengthroot canal irrigantsroot canal therapy

Identifiers

PMID40245338
PMCPMC12159787

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.