Evidence map›Paper›PMID 40245149›Full record

ArticleScience (New York, N.Y.)2025

The genetic architecture of cell type-specific cis regulation in maize.

Alexandre P Marand, Luguang Jiang, Fabio Gomez-Cano, Mark A A Minow, Xuan Zhang, John P Mendieta, Ziliang Luo, Sohyun Bang, Haidong Yan, Cullan Meyer and 3 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Hybrid origin and phenotype evolution of the modern maize.Journal of integrative plant biology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. From Structure to Function of Promoters and 5'UTRs in Maize.International journal of molecular sciences · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandre P MarandDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0001-9100-8320
Luguang JiangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7155-5471
Fabio Gomez-CanoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2624-0112
Mark A A MinowDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0002-0791-9621
Xuan ZhangDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0002-6635-371X
John P MendietaDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0002-7858-7302
Ziliang LuoDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0001-8720-0133
Sohyun BangInstitute of Bioinformatics, University of Georgia, Athens, GA, USA.ORCID 0000-0003-2058-1079
Haidong YanDepartment of Genetics, University of Georgia, Athens, GA, USA.
Cullan MeyerDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0003-1190-5764
Luca SchlegelPlant Epigenomics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.ORCID 0000-0002-8200-9388
Frank JohannesPlant Epigenomics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.ORCID 0000-0002-7962-2907
Robert J SchmitzDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID 0000-0001-7538-6663

Funding

T32 Predoctoral Training Grant in GeneticsT32GM142623 · NIGMS · UNIVERSITY OF GEORGIA · PI Kelly A Dyer, Mary Grace Goll · 2022 to 2026
$2.1M
Exploration of cis-regulatory diversity underlying phenotypic innovationR00GM144742 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARAND, ALEXANDRE · 2023 to 2025
$747k
Exploration of cis-regulatory diversity underlying phenotypic innovationK99GM144742 · NIGMS · UNIVERSITY OF GEORGIA · PI MARAND, ALEXANDRE · 2022 to 2023
$142k
NIGMS NIH HHS K99 GM144742NIGMS NIH HHS R00 GM144742NIGMS NIH HHS T32 GM142623
6 · The paper itself

Abstract

Gene expression and complex phenotypes are determined by the activity of cis-regulatory elements. However, an understanding of how extant genetic variants affect cis regulation remains limited. Here, we investigated the consequences of cis-regulatory diversity using single-cell genomics of more than 0.7 million nuclei across 172

Indexed as

Gene Expression Regulation, PlantRegulatory Sequences, Nucleic AcidZea maysBinding SitesChromatinDNA Transposable ElementsFlowersGenetic VariationGenome, PlantPlant ProteinsSingle-Cell AnalysisChromatinDNA Transposable ElementsPlant Proteins

Identifiers

PMID40245149
PMCPMC12183665

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.