ReviewPLoS neglected tropical diseases2025
The role of γδ T cells in flavivirus infections: Insights into immune defense and therapeutic opportunities.
Review in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host.Reviews in medical virology · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
γδ T cells are a unique subset of unconventional T cells and an important component of the innate immune system. Unlike conventional αβ T cells, γδ T cells can respond rapidly during the early stages of infection, and their antigen recognition is not restricted by MHC molecules. These distinctive features underscore the important role of γδ T cells in viral clearance and infection control. Therefore, γδ T cell-based immunotherapies have been extensively explored for the treatment of a variety of diseases, including viral infections and cancers. Several therapeutic strategies based on γδ T cells have advanced to clinical trials, demonstrating promising safety and efficacy. Currently, there are no effective treatments for flavivirus infections, which are typically characterized by acute onset. Research has shown that γδ T cells can rapidly expand during the early phases of flavivirus infections and effectively suppress viral replication, making them an attractive target for the development of novel therapies for flavivirus infections. This review aims to highlight the immunological roles of γδ T cells in flavivirus infections and to explore the potential of γδ T cell-based therapeutic strategies for the prevention and treatment of these infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.