Evidence map›Paper›PMID 40244983›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025

Cortisol, dehydroepiandrosterone, and depressive symptoms as pathways from child abuse to obesity.

Elizabeth D Handley, Justin Russotti, Dante Cicchetti, Rachel Y Levin, Andrew Ross

Abstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elizabeth D HandleyMt. Hope Family Center, University of Rochester.ORCID 0000-0002-0087-0263
Justin RussottiMt. Hope Family Center, University of Rochester.
Dante CicchettiMt. Hope Family Center, University of Rochester.
Rachel Y LevinMt. Hope Family Center, University of Rochester.
Andrew RossMt. Hope Family Center, University of Rochester.

Funding

Chronic Stress of Maltreatment: Drug Use VulnerabilityR01DA017741 · NIDA · UNIVERSITY OF ROCHESTER · PI CICCHETTI, DANTE CICCHETTI, ROGOSCH, FRED A · 2004 to 2016
$5.1M
Child Abuse and Trauma Related Psychopathology: Multiple Levels of AnalysisR01MH083979 · NIMH · UNIVERSITY OF ROCHESTER · PI CICCHETTI, DANTE CICCHETTI, ROGOSCH, FRED A · 2009 to 2013
$3.2M
Understanding Risk Heterogeneity Following Child Maltreatment: An Integrative Data Analysis Approach.K01HD112516 · NICHD · UNIVERSITY OF ROCHESTER · PI Justin Russotti · 2023 to 2026
$462k
Child Maltreatment: Innovative Methods for Probing Stress Regulatory Systems and Polygenic Moderation in Child PsychopathologyR03HD103779 · NICHD · UNIVERSITY OF ROCHESTER · PI HANDLEY, ELIZABETH DIPAOLA, TOTH, SHEREE LYNN · 2021 to 2022
$153k
National Institute of Child Health and Human DevelopmentNational Science FoundationNICHD NIH HHS K01 HD112516NICHD NIH HHS L40 HD109871NICHD NIH HHS R03 HD103779NIDA NIH HHSNIDA NIH HHS R01 DA017741NIMH NIH HHSNIMH NIH HHS R01 MH083979
6 · The paper itself

Abstract

objectiveChild abuse has been linked with obesity throughout the lifespan. The aim of the current study was to test two competing mechanisms underlying the association between child abuse exposure and obesity in childhood. Specifically, we examined whether depressive symptoms and the ratio of cortisol to dehydroepiandrosterone (DHEA), two hormones central to the stress response system, mediated the link between child abuse and obesity.

methodThis study employed a sample of 1,229 children all experiencing poverty (63.5% Black, 49.1% biological females). Approximately 40% of the participants were exposed to childhood physical, sexual, and/or emotional abuse (

resultsResults of structural equation modeling indicated that children with abuse histories evidenced a lower cortisol/DHEA ratio, which was associated with a greater likelihood of childhood obesity. Importantly, this pathway held while controlling for a depressive symptom pathway, pointing to the unique influence of adrenocortical dysregulation in the child abuse-obesity link. Although child abuse was associated with greater depressive symptoms, depressive symptoms were not related to obesity.

conclusionThese findings underscore that childhood adversity can "get under the skin" to affect health, even as early as childhood, and highlight that trauma-informed approaches to the clinical care of children with abuse histories represent a promising avenue for obesity prevention. Preventing child abuse occurrence and supporting children following abuse exposure may both be critical points of intervention for obesity prevention. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Indexed as

Child AbuseDehydroepiandrosteroneDepressionHydrocortisonePediatric ObesityAdolescentChildFemaleHumansMalePovertySalivaDehydroepiandrosteroneHydrocortisone

Identifiers

PMID40244983
PMCPMC12353486

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.