ArticleThe Plant cell2025
The transcription factor MYB30 promotes iron homeostasis by maintaining the stability of the FIT transcription factor.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- MPK3-mediated phosphorylation inactivates MYB4 to promote FIT-dependent iron acquisition.EMBO reports · 2026Article
- OsWRKY18 attenuates proteasomal degradation of OsbZIP48 to orchestrate zinc homeostasis in rice.The New phytologist · 2026Article
- Integrated Physiological and Transcriptomic Analyses Reveal That Arbuscular Mycorrhizal Symbiosis Enhances Iron Stress Tolerance inPlants (Basel, Switzerland) · 2026Article
- Review
- Genome-Wide Study of MYB Transcription Factors in Maize and Their Essential Roles in Male Fertility and Other Biological Processes.International journal of molecular sciences · 2026Article
- CITF1 interacts with FIT and regulates copper-iron crosstalk in Arabidopsis.The Plant cell · 2026Article
- Chloroplast ionome characterization provides new avenues to shape organellar iron homeostasis.The Plant cell · 2026Article
- Pumping iron, keeping FIT: How MYB30 regulates FIT stability during plant iron deficiency.The Plant cell · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Iron (Fe) is a vital nutrient for the growth and development of plants. In Arabidopsis (Arabidopsis thaliana), the bHLH transcription factor FER-LIKE IRON-DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) plays a pivotal role in regulating the response to Fe deficiency. Our study reveals that the R2R3-MYB transcription factor MYB30 is a positive regulator of the Fe-deficiency response by regulating FIT stability. Plants with loss-of-function mutations in MYB30 exhibit pronounced Fe-deficiency symptoms and diminished Fe uptake, while overexpression of MYB30 leads to the opposite effects. We have discovered that MYB30 interacts with BRUTUS LIKE1 (BTSL1) and BTSL2, 2 partially redundant E3 ubiquitin ligases that negatively regulate the Fe-deficiency response. MYB30 binds to the C-terminal region of BTSL1 through its MYB DNA-binding domain, thereby safeguarding FIT from BTSL1-mediated ubiquitination and degradation, resulting in FIT accumulation for Fe-deficiency response. In summary, our research uncovers the role of the transcription factor MYB30 as a regulator of FIT stability, which in turn modulates Fe homeostasis in plants in response to Fe deficiency.
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