ArticleAnnals of clinical and translational neurology2025
The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.Circulation · 2026Pooled it
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Characteristics of brain structural damage related to cerebral small vessel disease in general population with intracranial artery stenosis.Stroke and vascular neurology · 2026Article
- Association of Intracranial Plaque Features with the Severity of White Matter Hyperintensities in Middle-Aged and Older Community-Dwelling Adults.Biomedicines · 2025Article
- A radiomics-based approach with automated segmentation for identifying symptomatic basilar artery plaques in acute stroke.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveExploring the prevalence and association between intracranial atherosclerosis (ICAS) and cerebral small vessel diseases (CSVD), this study delved beyond the current scope, utilising high-resolution vessel wall MRI (HRVW-MRI) to investigate how subtle changes in intracranial atherosclerotic features influence the various burdens of CSVD.
methodsStroke-free Chinese adult participants were recruited from our ongoing community-based MRI cohort. HRVW-MRI technique with a T1-weighted 3D SPACE sequence was used to assess atherosclerotic plaque features: plaque load, degree of stenosis, remodelling index, eccentricity. A multi-sequence MRI assessment elucidated CSVD markers, including white matter hyperintensities, lacune infarcts, microbleeds and enlarged perivascular spaces. Statistical analyses, including sensitivity and specificity tests, chi-square, correlation and regression models were fitted to explore the association between ICAS and CSVD.
resultsOf the 225 participants (mean age 64.90 ± 6.87 years) included in the study, 101 (45%) were males. Thirty-nine participants (17.3%) presented with ICAS (8 progressive plaques and 31 were pre-atherosclerotic). One hundred and six (47.1%) participants recorded at least one clinically significant marker of CSVD. The subtle changes (increment or decrement) in atherosclerotic features such as positive remodelling, plaque load, eccentricity, degree of stenosis and the morphology (ICAS severity) may parallelly influence the distinct markers and overall CSVD burden.
interpretationThis study demonstrates that the association between ICAS and CVSD extends beyond mere co-existence due to shared risk factors, suggesting the presence of a dose-effect relationship between ICAS and CVSD. HRVW-MRI could elucidate diagnostic metrics and characteristic features that reveal how ICAS impacts distinct CSVD burdens, thereby enhancing clinical decisions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.