Evidence map›Paper›PMID 40244679›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction.

Tatsuhiko Yokoyama, Ryoji Miyazaki, Takehiro Suzuki, Naoshi Dohmae, Hiroki Nagai, Tomoya Tsukazaki, Tomoko Kubori, Yoshinori Akiyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatsuhiko YokoyamaDepartment of Microbiology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.ORCID 0000-0003-3122-6822
Ryoji MiyazakiDivision of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.ORCID 0000-0003-1626-2569
Takehiro SuzukiBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan.ORCID 0000-0002-0585-6305
Naoshi DohmaeBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan.ORCID 0000-0002-5242-9410
Hiroki NagaiDepartment of Microbiology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.ORCID 0000-0003-1659-2197
Tomoya TsukazakiDivision of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan.ORCID 0000-0002-6386-723X
Tomoko KuboriDepartment of Microbiology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan.ORCID 0000-0003-1098-6021
Yoshinori AkiyamaDepartment of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.ORCID 0000-0003-4483-5408

Funding

Institute for Fermentation, Osaka (IFO) Y-2023-2-023MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05155MEXT | Japan Society for the Promotion of Science (JSPS) JP22H02571/23K23835MEXT | Japan Society for the Promotion of Science (JSPS) JP22K15061MEXT | Japan Society for the Promotion of Science (JSPS) JP23KJ1581MEXT | Japan Society for the Promotion of Science (JSPS) JP24H01370MEXT | Japan Society for the Promotion of Science (JSPS) JP24K17817
6 · The paper itself

Abstract

TonB-dependent signal transduction is a versatile mechanism observed in gram-negative bacteria that integrates energy-dependent substrate transport with signal relay. In

Indexed as

Escherichia coliEscherichia coli ProteinsMembrane ProteinsSigma FactorSignal TransductionFerric CompoundsGene Expression Regulation, BacterialProteolysisReceptors, Cell SurfaceEscherichia coli ProteinsFecA protein, E coliferric citrateFerric CompoundsMembrane ProteinsReceptors, Cell SurfaceSigma FactortonB protein, E coliFec systemiron transportsignal transductionTat systemTon system

Identifiers

PMID40244679
PMCPMC12036975

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.