ArticleProceedings of the National Academy of Sciences of the United States of America2025
Pulse timing dominates binaural hearing with cochlear implants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Neurophysiological sensitivity to envelope and pulse timing interaural time differences in cochlear implanted rats with different hearing experiences.The Journal of physiology · 2026Article
- Binaural sensitivity and processing of envelope-based interaural difference cues by bilateral cochlear implant users with perilingual and postlingual onset of deafness.The Journal of the Acoustical Society of America · 2026Article
- Best cochlear locations for delivering interaural timing cues in electric hearing.Communications medicine · 2026Article
- Interactions of Interaural Time and Level Differences in Spatial Hearing with Cochlear Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A deep learning framework for understanding cochlear implants.bioRxiv : the preprint server for biology · 2025Article
- Personalizing Cochlear Implant Care in Single-Sided Deafness: A Distinct Paradigm from Bilateral Hearing Loss.Journal of personalized medicine · 2025Review
- Pulse timing dominates binaural hearing with cochlear implants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- When the First Pulse Fades: 75% Reduction in Precedence Effect in Cochlear Implanted Rats.Trends in hearingArticle
- Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints.Trends in hearingReview
- Transmission of Binaural Cues by Bilateral Cochlear Implants: A Comparison of Spectral Peak-Picking and Interleaved Stimulation Strategies.Trends in hearingArticle
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Authors and funding
6 authors.
Funding
Abstract
Although cochlear implants (CIs) provide valuable auditory information to more than one million profoundly deaf patients, these devices remain inadequate in conveying fine timing cues. Early deaf patients in particular struggle to use interaural time differences (ITDs) for spatial hearing and auditory scene analysis. Why CI patients experience these limitations remains controversial. One possible explanation, which we investigate here, is that the stimulation by clinical CIs is inappropriate, as it encodes temporal features of sounds only in the envelope of electrical pulse trains, not the pulse timing. We have recently demonstrated that early deaf, adult implanted rats fitted with bilateral CIs that deliver carefully timed pulses routinely develop sensitivity to very small ITDs. Here we show that, while the early deafened mammalian auditory pathway can innately easily resolve pulse timing ITDs as small as 80 µs, it is many times less sensitive to the ITDs of pulse train envelopes. Our results indicate that the stimulation strategies in current clinical use do not present ITD cues in a manner that the inexperienced auditory pathway is highly sensitive to. This may deprive early deaf CI patients of the opportunity to hone their submillisecond temporal processing skills as they learn to hear through their prosthetic devices.
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