Evidence map›Paper›PMID 40244664›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Verapamil and its metabolite norverapamil inhibit the

Adam J Fountain, Natalie J E Waller, Chen-Yi Cheung, William Jowsey, Michael T Chrisp, Mark Troll, Paul H Edelstein, Gregory M Cook, Matthew B McNeil, Lalita Ramakrishnan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Frontiers in cellular and infection microbiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Structural and functional analysis of theProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam J Fountain *Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Natalie J E Waller *Department of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.
Chen-Yi CheungDepartment of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.
William JowseyDepartment of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.
Michael T ChrispDepartment of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.
Mark TrollMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Paul H EdelsteinMedical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-4069-5279
Gregory M Cook *Department of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.ORCID 0000-0001-8349-1500
Matthew B McNeil *Department of Microbiology and Immunology, University of Otago, Dunedin 9053, New Zealand.ORCID 0000-0001-7747-7745
Lalita Ramakrishnan *Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-0692-5533

Funding

Host Responses to Mycobacterium Infection in ZebrafishR01AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI LALITA RAMAKRISHNAN · 2003 to 2026
$4.4M
Host-Responses to Mycobacterium Infection in ZebrafishR37AI054503 · NIAID · UNIVERSITY OF WASHINGTON · PI RAMAKRISHNAN, LALITA · 2012 to 2021
$3.1M
Maurice Wilkins Centre for Molecular Biodiscovery and the Marsden Fund (Royal Society of New Zealand) UOO1807NIAID NIH HHS R01 AI054503NIAID NIH HHS R37 AI054503Wellcome Trust 223103Wellcome Trust (WT) 223103/Z/21/Z
6 · The paper itself

Abstract

Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of

Indexed as

Antitubercular AgentsBacterial ProteinsDiarylquinolinesMembrane Transport ProteinsMycobacterium tuberculosisVerapamilDrug Resistance, BacterialMicrobial Sensitivity TestsAntitubercular AgentsBacterial ProteinsbedaquilineDiarylquinolinesMembrane Transport ProteinsVerapamilbedaquilineMmpS5L5 drug efflux pumpMycobacterium tuberculosisTBAJ-587 and TBAJ-876verapamil and norverapamil

Identifiers

PMID40244664
PMCPMC12036985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.