Evidence map›Paper›PMID 40244652›Full record

ArticleJMIR formative research2025

Creating a Usable and Effective Digital Intervention to Support Men to Test for HIV and Link to Care in A Resource-Constrained Setting: Iterative Design Based on A Person-Based Approach and Human Computer Interaction Methods.

Anya Zeitlin, Thulile Mathenjwa, Thembelihle Zuma, Sally Wyke, Philippa Matthews, Nuala McGrath, Janet Seeley, Maryam Shahmanesh, Ann Blandford

Abstract read
In one paragraph

Article in JMIR formative research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anya Zeitlin *UCL Interaction Centre, University College London, London, United Kingdom.ORCID 0000-0003-3386-8001
Thulile Mathenjwa *Africa Health Research Institute, Durban, South Africa.ORCID 0000-0003-2436-9972
Thembelihle ZumaAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0002-8374-2354
Sally WykeSchool of Social and Political Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-7509-8247
Philippa MatthewsAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0002-6157-9680
Nuala McGrathAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0002-1039-0159
Janet SeeleyAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0002-0583-5272
Maryam ShahmaneshAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0001-7129-8535
Ann BlandfordUCL Interaction Centre, University College London, London, United Kingdom.ORCID 0000-0002-3198-7122

Funding

Can HIV Hot-Spots be eradicated? An intervention to decrease HIV transmission to young women in rural KwaZulu-Natal South AfricaR01AI124389 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2016 to 2020
$2.1M
NIAID NIH HHS R01 AI124389Wellcome Strategic Core award 227167/A/23/ZWellcome TrustWellcome Trust 082384/Z/07/Z
6 · The paper itself

Abstract

backgroundIt is challenging to design usable and effective digital health interventions (DHIs). The person-based approach (PBA) has been proposed to incorporate users' perspectives for the design of DHIs. However, it does not explicitly describe the iterative stages of design and evaluation that are essential in moving from early planning to deployment. For this, we draw on methods from human computer interaction (HCI) that have been developed for various situations.

objectiveThis study aimed to reflect on the adaptation and synthesis of PBA and HCI approaches to developing DHIs. We present a case study applying both approaches to develop Empowering People through Informed Choices for HIV (EPIC-HIV1), a DHI designed for men living in rural KwaZulu-Natal, South Africa, intended to support them in making an informed choice about whether to take an HIV test and, if necessary, engage in care.

methodsWe conducted a retrospective analysis of the documentation generated during the development of EPIC-HIV1 including findings about requirements, design representations, and the results of iterative rounds of testing. We developed an account of the process, the outcomes, and the strengths and limitations of the design and evaluation techniques applied. We also present the design of EPIC-HIV1 and summarize considerations when designing for hard-to-reach people in such settings.

resultsThe PBA was applied to deliver a first prototype. This helped identify key messages to convey and how to manage issues such as user privacy, but the resulting prototype was judged by the team not to be engaging for potential users, and it was unclear whether the design was inclusive of people with low digital or health literacy. We therefore introduced methods from HCI to iteratively test and refine the app. Working with local community representatives, we conducted four refinement cycles with 29 participants, adapting and retesting the app until no further changes were needed. Key changes included making it clearer what the consequences of selecting options in the app were and changing wording to minimize misconceptions (eg, that the app would test for HIV) while addressing common concerns about testing and emphasizing long-term benefits of engaging with care, if needed.

conclusionsTechniques for developing DHIs need to be situationally appropriate. The PBA enabled us to establish both empirical data and theory to design the content of EPIC-HIV1, but it did not directly inform interaction design to make the app usable and effective for the intended users; HCI techniques tailored to the setting enabled us to refine the app to be easy for men with little familiarity with digital technologies to use within the constraints of the setting. Iterative testing ensured the app was easy to use and that the intended clinical messages were communicated effectively.

Indexed as

HIV InfectionsHIV TestingUser-Computer InterfaceAdultHumansMaleRetrospective StudiesSouth AfricaTelemedicinebehavior change techniquesdigital healthdigital interventionHIVperson-based approachresource-constrained settingsuser-centered design

Identifiers

PMID40244652
PMCPMC12046270

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.