Evidence map›Paper›PMID 40244568›Full record

SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2025

Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A systematic review and a meta-analysis of prevalence.

Emma Bonetti, Gloria Anderson, Simona Duranti, Federico Ferrari, Franco Odicino, Antonia Testa, Francesco Fanfani, Giovanni Scambia, Ursula Catena

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical features and surgical options of obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A systematic review and a meta-analysis of prevalence.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Pooled it
  2. Spontaneous Urinary Bladder Rupture Secondary to OHVIRA Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emma BonettiDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0009-0005-0836-5260
Gloria AndersonScientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0003-2929-9328
Simona DurantiScientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Federico FerrariDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Franco OdicinoDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Antonia TestaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Francesco FanfaniUniversità Cattolica del Sacro Cuore, Rome, Italy.
Giovanni ScambiaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Ursula CatenaDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOHVIRA syndrome, a urogenital malformation, lacks standardized management. Narrative reviews exist, but there is no a comprehensive meta-analysis.

objectivesThe aim of this first systematic review and meta-analysis is to evaluate the current literature and inform management strategies. SEARCH STRATEGY: We searched Scopus, Medline, Embase and Web of Science, up to March 2024. SELECTION CRITERIA: Case series, case reviews, and longitudinal studies on patients with OHVIRA syndrome. DATA COLLECTION AND ANALYSIS: Data were extracted and meta-analyzed using R software. MAIN

resultsIn all, 35 studies (1988-2022) with 526 patients were included. Average symptom onset was 14.45 years, and diagnosis at 16.36 years suggests potential delays. The most common symptoms were abdominal pain (67%, 95% CI 54-77, I

conclusionsEarly diagnosis and surgery are crucial to prevent complications. Vaginal septum resection remains the gold standard, while hysteroscopy offers a promising minimally invasive alternative.

Indexed as

Congenital AbnormalitiesKidneyKidney DiseasesUrogenital AbnormalitiesVaginaAbdominal PainDysmenorrheaFemaleHumansLaparoscopyPrevalenceHerlyn–Werner–Wunderlich syndromeobstructed hemivaginaOHVIRA syndromevaginal septum resection

Identifiers

PMID40244568
PMCPMC12447673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.