Evidence map›Paper›PMID 40244536›Full record

ReviewBreast cancer research and treatment2025

Targeting breast cancer: the promise of phage-based nanomedicines.

Sarah Gholami, Hossein Saffarfar, Mohammad Reza Mehraban, Nastaran Safavi Ardabili, Anis Elhami, Sara Ebrahimi, Payam Ali-Khiavi, Reza Kheradmand, Seyedeh Farinaz Fattahpour, Ahmad Mobed

Abstract readReview
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In one paragraph

Review in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah GholamiYoung Researcher and Elite Club, Islamic Azad University, Babol Branch, Babol, Iran.
Hossein SaffarfarCardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza MehrabanYoung Researchers and Elite Club, Babol Branch,, Islamic Azad University, Babol, Iran.
Nastaran Safavi ArdabiliDepartment of Midwifery, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
Anis ElhamiAhvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Sara EbrahimiFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Payam Ali-KhiaviFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza KheradmandFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Seyedeh Farinaz FattahpourFaculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. safattah@yahoo.com.
Ahmad MobedSocial Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. mobed1980@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is a leading cause of cancer-related mortality among women worldwide, characterized by its aggressive nature, propensity for metastasis, and resistance to standard treatment modalities. Traditional therapies, including surgery, chemotherapy, and radiation, often encounter significant limitations such as systemic toxicity and lack of specificity.

objectiveThis review aims to evaluate the recent advancements in phage-based nanomedicines as a novel approach for targeted breast cancer therapy, focusing on their mechanisms of action, therapeutic benefits, and the challenges faced in clinical implementation.

methodsA comprehensive literature review was conducted, analyzing studies that investigate the application of bacteriophages in cancer therapy, particularly in breast cancer. The review highlights the integration of nanotechnology with phage therapy, examining the potential for enhanced targeting and reduced side effects.

resultsPhage-based nanomedicines have shown promise in selectively targeting breast cancer cells while sparing healthy tissues, thereby improving therapeutic efficacy and safety profiles. The unique properties of bacteriophages, including their ability to be engineered for specific targeting and their natural ability to induce immune responses, present significant advantages over conventional treatments.

conclusionThe integration of phage therapy with nanotechnology represents a promising frontier in the fight against breast cancer. This review underscores the need for continued research to address existing challenges and to explore the full potential of phage-based nanomedicines in improving patient outcomes in breast cancer treatment.

Indexed as

BacteriophagesBreast NeoplasmsNanomedicinePhage TherapyAnimalsFemaleHumansBreast cancerNanomedicineNanotechnologyPhage therapy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.