Evidence map›Paper›PMID 40244498›Full record

ReviewReviews in endocrine & metabolic disorders2026

Hypothalamic control of heart rate and body temperature by thyroid hormones.

Jens Mittag, Beke Kolms

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Hypothalamic wars: the last nanodelivery.Reviews in endocrine & metabolic disorders · 2026
    Review
  3. Hypothalamus-liver talks: whispers in the language of metabolism.Reviews in endocrine & metabolic disorders · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jens MittagInstitute for Experimental Endocrinology, Center of Brain Behavior & Metabolism (CBBM), University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany. jens.mittag@uni-luebeck.de.ORCID 0000-0001-7778-5158
Beke KolmsInstitute for Experimental Endocrinology, Center of Brain Behavior & Metabolism (CBBM), University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.ORCID 0009-0000-7413-9097

Funding

Deutsche Forschungsgemeinschaft 424957847 and 445465132
6 · The paper itself

Abstract

As evidenced by the clinical symptoms in hyper- or hypothyroidism, thyroid hormones have strong effects on cardiovascular and metabolic functions. While these actions had been initially attributed to direct molecular mechanisms in the respective peripheral tissues such as heart, muscle or adipose tissue, a recent paradigm shift has occurred with accumulating observations that demonstrated important indirect effects via the brain on these systems. However, the individual contributions of the peripheral versus central thyroid hormone actions for the well-known phenotypical symptoms are still not entirely understood. Similarly, the neuroanatomical substrates for these central actions have remained largely enigmatic, although many studies point to the hypothalamus as a major target of thyroid hormone action. This review critically discusses the role of the central actions of thyroid hormone for the regulation of heart rate, body temperature, energy expenditure and food intake, and integrates some novel findings to summarize the current state of the field.

Indexed as

Body TemperatureHeart RateHypothalamusThyroid HormonesAnimalsEnergy MetabolismHumansThermogenesisThyroid HormonesBrown fatEnergy expenditureHeartThermogenesisThyroid hormone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.