Evidence map›Paper›PMID 40244442›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Participation in life activities after hematopoietic cell transplantation in older adults.

Natalie von Oldenburg, Noelle Pick, Jessica N Semin, Marcia Free, Weston Ernst, Diane M Hill-Polerecky, Kimberly A Miller, Vijaya R Bhatt, Tanya M Wildes, Paul A Estabrooks and 3 more

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Natalie von OldenburgDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Noelle PickDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Jessica N SeminDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Marcia FreeDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Weston ErnstDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Diane M Hill-PolereckyBlood and Marrow Transplantation Program, Nebraska Medicine, Omaha, NE, USA.
Kimberly A MillerBlood and Marrow Transplantation Program, Nebraska Medicine, Omaha, NE, USA.
Vijaya R BhattDivision of Hematology Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Fred & Pamela Buffett Cancer Center, Omaha, NE, USA.
Tanya M WildesDivision of Hematology Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Fred & Pamela Buffett Cancer Center, Omaha, NE, USA.
Paul A EstabrooksDepartment of Health and Kinesiology, University of Utah, Salt Lake City, UT, USA.
Alfred L FisherDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA.
Katherine J JonesNebraska Coalition for Patient Safety, Omaha, NE, USA.
Thuy T KollDivision of Geriatrics, Gerontology, and Palliative Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 986155 Nebraska Medical Center Omaha, NE 68198 - 6155, Omaha, NE, USA. thuy.koll@unmc.edu.

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
Aging trajectories and outcomes of older adults with acute myeloid leukemiaR37CA276928 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Vijaya Raj Bhatt · 2023 to 2026
$2.1M
Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation (HCT)K23AG070311 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KOLL, THUY · 2021 to 2025
$1.1M
NCI NIH HHS P30 CA036727NCI NIH HHS R37 CA276928NIA NIH HHS K23 AG070311NIA NIH HHS K23AG070311
6 · The paper itself

Abstract

objectivesThis study aims to measure activity participation and describe barriers and goals for participation in older adults post-HCT. MATERIALS AND

methodsIn a convergent mixed methods design, we quantitatively assessed four domains of participation (instrumental, low demand leisure, high demand leisure, and social) using the modified Activity Card Sort (ACSm) and described cognitive, physical, and psychosocial function using validated measures. Semi-structured interviews were used to describe barriers and goals for participation.

resultsEighteen participants with the median age of 66 years (range 60-75 years) completed the ACSm and interview. Seventeen of the 18 participants were > 6 months post-HCT and 44% of the total participants were > 12 months out from transplant. Overall, participants returned to 80% of their total activities. Mean retention was the highest in low-demand leisure activities (89%), followed by instrumental (85%), social (77%), and high-demand leisure activities (59%). Fatigue and impaired physical function were barriers for all activity domains. Participants discussed cognitive function as a barrier for many instrumental and low-demand leisure activities. Side effects, complications (i.e., osteoporosis and GVHD) and immune suppression were barriers to high-demand leisure activities. Participants talked about the meaning and purpose behind activity participation, highlighting the centrality of returning to life activities despite ongoing symptoms. There were multiple goals discussed related to activity participation.

conclusionOlder adults undergoing HCT have diminished functional reserve and need more time to recover from activities that require sustained energy. Physical activity promotion programs targeting activity limitations and participation restrictions in cancer survivors are particularly salient for older adults undergoing HCT.

Indexed as

Activities of Daily LivingHematopoietic Stem Cell TransplantationLeisure ActivitiesAgedCognitionFemaleHumansInterviews as TopicMaleMiddle AgedQuality of LifeSocial ParticipationHematopoietic cell transplantLived experiencePhysical activityQuality of lifeSurvivorship

Identifiers

PMID40244442
PMCPMC12218019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.