Molecular transport through nano-sized multipores of lipid vesicles: a COMSOL simulation study.

Md Asaduzzaman, Shahariar Emon, Md Saif Ishtiaque, Md Imran Hossain, Mahammad Abu Sayem Karal, Md Masum Billah, Hiromitsu Takaba, Md Khorshed Alam

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Article in European biophysics journal : EBJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Md AsaduzzamanDepartment of Physics, University of Barishal, Barishal, 8254, Bangladesh.

Shahariar EmonDepartment of Physics, University of Barishal, Barishal, 8254, Bangladesh.

Md Saif IshtiaqueDepartment of Physics, University of Barishal, Barishal, 8254, Bangladesh.

Md Imran HossainDepartment of Physics, University of Barishal, Barishal, 8254, Bangladesh.

Mahammad Abu Sayem KaralDepartment of Physics, Bangladesh University of Engineering and Technology, Dhaka, 1000, Bangladesh. asayem221@phy.buet.ac.bd.

Md Masum BillahDepartment of Physics, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.

Hiromitsu TakabaDepartment of Environmental Chemistry and Chemical Engineering, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano Hachioji, Tokyo, 192-0015, Japan.

Md Khorshed AlamDepartment of Physics, University of Barishal, Barishal, 8254, Bangladesh. dmkalam@bu.ac.bd.ORCID http://orcid.org/0000-0002-3925-4900

Funding

Ministry of Science and Technology, Government of the People's Republic of Bangladesh SRG-231319

6 · The paper itself

Abstract

Biomembranes regulate molecular transport essential to cellular function and numerous biomedical applications, such as drug delivery and gene therapy. This study simulates molecular transport through nano-sized multipores in Giant Unilamellar Vesicles (GUVs) using COMSOL Multiphysics. We analyzed the diffusion dynamics of fluorescent probes-including Calcein, Texas-red dextran 3000 (TRD- 3k), TRD- 10k, and Alexa Fluor-labeled soybean trypsin inhibitor (AF-SBTI)-across different pore sizes, and derived rate constants using curve fitting that closely align with experimental data. Additionally, an analytical model based on Fick's law of diffusion provides further insight into transport efficiency. This approach offers a novel perspective by examining simultaneous transport through multiple nanopores, which better mimics realistic biological environments compared to traditional single-pore studies. We used COMSOL for efficiently simulating large-scale, multi-nanopore systems, particularly in biomedical applications where modeling of complex transport phenomena is essential. This work provides new insights into multipore-mediated transport, critical for optimizing nanopore-based drug delivery and advancing the understanding of cellular transport mechanisms.

Indexed as

NanoporesUnilamellar LiposomesBiological TransportDiffusionUnilamellar LiposomesCOMSOL multiphysics simulationFluorescent probe diffusionMolecular transportMulti-nanopore diffusionMultipore of GUVsNanopore-mediated transport

Identifiers

PMID40244405

DOI10.1007/s00249-025-01745-z

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.