Trial reportLasers in medical science2025
Changes in posterior corneal elevation and associated factors following small incision lenticule extraction in patients with high myopia and thin cornea: a prospective randomized clinical study.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Posterior corneal elevation changes after small incision lenticule extraction in patients with thin cornea.International journal of ophthalmology · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
To investigate the safety and efficacy of SMILE in patients with high myopia and analyzed the factors influencing corneal posterior elevation variation (PCE). This was a prospective, comparative, randomized, clinical study. Patients with a corneal thickness < 530 μm at the thinnest point of the right eye with a spherical equivalent (SE) ≤-3.00D (group A: ≤-3.00D, >-6.00D; group B: ≤-6.00D, >-10.00D) who underwent SMILE surgery between January 1, 2020, and May 31, 2021 were randomly selected. We compared the difference in postoperative vertex PCE between the two groups and assessed the correlation between PCE variation (△PCE) and corneal biomechanical parameters. The preoperative SE was - 4.74 ± 0.63D and - 7.38 ± 1.22D in groups A (41 eyes) and B (37 eyes), respectively. PCE was 0.61 ± 2.07 and 0.16 ± 2.19 μm, and △PCE was - 0.93 ± 1.13 and - 1.43 ± 1.07 μm in groups A and B, respectively, showing significant differences (P < 0.05). △A2L and △A2V (r=-0.41, -0.36; P = 0.02, 0.04) were correlated with △PCE. Stepwise regression analysis showed that △A2L was the predictor variable of △PCE (AIC = 0.8, P = 0.02). SMILE surgery is safe and effective for correcting high myopia with a thin cornea. A2L may affect the variation of vertex PCE following SMILE surgery. The higher reduction in A2L indicates less PCE backward displacement.
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Registered trials
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