Evidence map›Paper›PMID 40244393›Full record

ArticleInternational journal of molecular sciences2025

A Large Multicenter Brazilian Case-Control Study Exploring Genetic Variations in Interferon Regulatory Factor 6 and the Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate.

Renato Assis Machado, Daniella Reis Barbosa Martelli, Silvia Regina de Almeida Reis, Luiz Evaristo Ricci Volpato, Rafaela Scariot, Juliana Feltrin-Souza, Ana Lúcia Carrinho Ayroza Rangel, Brazilian Oral Cleft Group, Hercílio Martelli-Júnior, Ricardo D Coletta

Abstract readMulticenter Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renato Assis MachadoDepartment of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-018, São Paulo, Brazil.
Daniella Reis Barbosa MartelliPrimary Care/Health Sciences Postgraduate Program, State University of Montes Claros, Montes Claros 39401-089, Minas Gerais, Brazil.ORCID 0000-0002-3979-7497
Silvia Regina de Almeida ReisDepartment of Basic Science, Bahiana School of Medicine and Public Health, Salvador 40290-000, Bahia, Brazil.
Luiz Evaristo Ricci VolpatoPostgraduate Program in Integrated Dental Sciences, Cuiaba School of Dentistry, University of Cuiaba, Cuiaba 78000-000, Mato Gosso, Brazil.ORCID 0000-0002-2969-1963
Rafaela ScariotDepartment of Stomatology, Federal University of Paraná, Curitiba 80120-170, Parana, Brazil.ORCID 0000-0002-4911-6413
Juliana Feltrin-SouzaDepartment of Stomatology, Federal University of Paraná, Curitiba 80120-170, Parana, Brazil.ORCID 0000-0001-9969-3721
Ana Lúcia Carrinho Ayroza RangelCenter of Biological Sciences and of the Health, School of Dentistry, State University of Western Paraná, Cascavel 85819-110, Paraná, Brazil.ORCID 0000-0003-1080-358X
Brazilian Oral Cleft Group
Hercílio Martelli-JúniorPrimary Care/Health Sciences Postgraduate Program, State University of Montes Claros, Montes Claros 39401-089, Minas Gerais, Brazil.
Ricardo D ColettaDepartment of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-018, São Paulo, Brazil.ORCID 0000-0001-5285-3046

Funding

The Minas Gerais State Research Foundation-FAPEMIG 001The National Council for Scientific and Technological Development-CNPq 402994/2023-0
6 · The paper itself

Abstract

Nonsyndromic cleft lip with or without cleft palate (NSCL ± P) is strongly associated with both environmental and genetic risk factors, but its genetic underpinnings remain partially known. While variants in interferon regulatory factor 6 (IRF6) are linked to NSCL ± P risk in populations from Asia and Europe, studies on the highly admixed Brazilian population are scarce and have produced ambiguous results. This study aimed to investigate the contribution of

Indexed as

Cleft LipCleft PalateGenetic Predisposition to DiseaseInterferon Regulatory FactorsPolymorphism, Single NucleotideAllelesBrazilCase-Control StudiesChildFemaleGene FrequencyGenotypeHumansMaleRisk FactorsInterferon Regulatory FactorsIRF6 protein, humancase-control studyIRF6nonsyndromic orofacial cleftsrisk factorsingle-nucleotide polymorphism

Identifiers

PMID40244393
PMCPMC11989878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.