SynthesisArchives of orthopaedic and trauma surgery2025
Survival impact of pathological fractures in metastatic cancer: a comprehensive meta-analysis.
Synthesis in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Anatomical distribution of bone metastases in stage IV breast cancer: According to histological subtype.World journal of clinical oncology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMetastatic patients face the risk of pathological fractures (PF). The incidence of PF varies among different cancer types, impacting patient survival and leading to substantial healthcare costs. However, conflicting findings regarding the survival impact of PF exist, and comprehensive meta-analyses addressing this issue are currently lacking. The aim of this study was to evaluate the survival of metastatic cancer patients with PF.
methodsThis study adhered to PRISMA guidelines and employed the PICOS strategy for inclusion criteria. A comprehensive search was conducted across multiple databases. The primary focus was on survival outcomes. Statistical analysis employed Review Manager 5.4.1, calculating mean differences for continuous variables and generic inverse variances for hazard ratios. Heterogeneity was assessed using Chi2 and I2 tests.
resultsA total of eight studies with 15,464 patients were included. Unadjusted hazard ratios (HRs) showed that PF increased the risk of mortality 1.45 (95% CI 1.22 to 1.73). Adjusted HRs confirmed significant increase in mortality risk for PF HR 1.31 (95% CI 1.08 to 1.57). The PF group had significant lower mean survival (MD -14.50, 95% CI -22.95 to -6.05). PF increased the risk of mortality in breast cancer (HR 1.52, 95% CI 1.32 to 1.76), prostate cancer (HR 1.38, 95% CI 1.16 to 1.64) and in leiomyosarcoma (HR 5.40, 95% CI 1.80 to 16.2).
conclusionPF increases the mortality risk and reduces the mean survival of patients with metastatic cancer.
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Registered trials
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