Evidence map›Paper›PMID 40244355›Full record

ArticleJournal of molecular histology2025

Preliminary assessment of cardiovascular effects and chemoinformatic analysis of total aqueous extract and fractions from Inula viscosa leaves.

Fatima El Hajji, Zineb Hakkou, Ayman M Al-Qaaneh, Moulay Hfid Youssoufi, Zachee Louis Evariste Akissi, Sevser Sahpaz, Chaimae Alla, Amal Zahi, Sanae Abid, Sergey Shityakov and 4 more

Abstract read
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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fatima El HajjiLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Zineb HakkouLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Ayman M Al-QaanehFaculty of Allied Medical Sciences, Al-Balqa Applied University (BAU), Al-Salt, 19117, Jordan. ayman.alqennh@bau.edu.jo.ORCID http://orcid.org/0000-0002-6342-6573
Moulay Hfid YoussoufiLaboratory of Applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Zachee Louis Evariste AkissiBioEcoAgro Joint Cross-Border Research Unit, UMRt 1158, Univ. Lille, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, Cité Scientifique, 59655, Villeneuve d'Ascq, France.
Sevser SahpazBioEcoAgro Joint Cross-Border Research Unit, UMRt 1158, Univ. Lille, Univ. Liège, UPJV, JUNIA, Univ. Artois, Univ. Littoral Côte d'Opale, Cité Scientifique, 59655, Villeneuve d'Ascq, France.
Chaimae AllaLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Amal ZahiLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Sanae AbidLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Sergey ShityakovDepartment of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.
Abderrahim ZiyyatLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Hassane MekhfiLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Mohamed BnouhamLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Abdelkhaleq LegssyerLaboratory of Bioresources, Biotechnology, Ethnopharmacology, and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inula viscosa (L.) Aiton [Dittrichia viscosa (L.) Greuter] (Asteraceae) is an evergreen perennial herb that grows in different regions of the Mediterranean Basin. It has been particularly used for the treatment of hypertension and diabetes in the Eastern and South-East regions of Morocco. To assess the cardiovascular effects of total aqueous extract and various fractions of Inula viscosa leaves in rat-isolated hearts and aortic rings, and to investigate the potential mechanisms of action of the most active extract(s). In Langendorff's isolated heart system, heart rate (HR) and left ventricular developed pressure (LVDP) were measured for three increasing concentrations of TAE, DCMF, EAF, BF, and AF (0.003, 0.03, and 0.3 mg/mL). Propranolol (1.5 × 10⁻

Indexed as

HeartPlant ExtractsPlant LeavesAnimalsAortaHeart RateMaleRatsRats, WistarVasodilator AgentsPlant ExtractsVasodilator AgentsAntioxidantChronotropicInotropicInula viscosaLangendorffMolecular dockingVasorelaxant

Identifiers

PMID40244355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.