ArticlePsychopharmacology2025
Assessment of abuse potential of furanylfentanyl and tetrahydrofuranylfentanyl.
Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.Psychopharmacology · 2026Article
- Fentanyl decreases blood oxygen more than furanylfentanyl despite similar effects on breathing.Research square · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationalFuranylfentanyl and tetrahydrofuranylfentanyl (THF-F) have been emerging in numerous intoxication and overdose cases in recent years. However, there remains a data deficiency regarding the abuse potential of these novel fentanyl analogs.
objectivesThis study was designed to systematically assess the abuse potential of furanylfentanyl and THF-F.
methodsIn this study, we evaluated the abuse potential of furanylfentanyl and THF-F via the conditioned place preference (CPP), drug self-administration, drug discrimination, and naloxone-precipitated withdrawal experiments with fentanyl as a reference.
resultsResults from CPP experiments indicated that furanylfentanyl and THF-F could induce CPP at minimum doses of 0.1 mg/kg and 3 mg/kg, respectively. These doses were 1 time and 30 times that of fentanyl (0.1 mg/kg). Furanylfentanyl elicited stable self-administration responses at 2.5 µg/kg/infusion, whereas THF-F did so at 50 µg/kg/infusion. In the drug-substitution test, furanylfentanyl and THF-F induced the maximum number of infusions at 1.10 µg/kg and 12.5 µg/kg, respectively, which were 1 time and 10 times that of fentanyl (1.21 µg/kg). In drug discrimination tests, all three substances were fully substituted for the discriminative-stimulus effects of heroin dose-dependently. The substitution potency of furanylfentanyl (ED
conclusionsTaken together, our study presented new evidence indicating that furanylfentanyl and THF-F exhibit significant abuse potential in rodent models, which provides experimental data for the control. Furthermore, our study offered valuable information for future studies into the addictive properties of structurally modified fentanyl analogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.