Evidence map›Paper›PMID 40244276›Full record

ArticleInternational journal of molecular sciences2025

Distinct T Cell Subset Profiles and T-Cell Receptor Signatures in Metabolically Unhealthy Obesity.

Yoona Chung, Ji Yeon Chang, Shindy Soedono, Vivi Julietta, Esther Jin Joo, Soon Hyo Kwon, Sung Il Choi, Yong Jin Kim, Kae Won Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoona ChungMetabolic and Bariatric Surgery Center, Department of Surgery, H+ Yangji Hospital, Seoul 08779, Republic of Korea.
Ji Yeon ChangSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0003-4490-5314
Shindy SoedonoSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0001-5252-893X
Vivi JuliettaSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Esther Jin JooSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Soon Hyo KwonDivision of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.ORCID 0000-0002-4114-4196
Sung Il ChoiDepartment of Surgery, Kyung Hee University Hospital at Gangdong, Seoul 05278, Republic of Korea.
Yong Jin KimMetabolic and Bariatric Surgery Center, Department of Surgery, H+ Yangji Hospital, Seoul 08779, Republic of Korea.
Kae Won ChoSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0001-7512-6722

Funding

Korea Health Industry Development Institute HI14C2092Korean Society for the Study of Obesity KSSO202401National Research Foundation of Korea NRF-2022R1A2C2006224
6 · The paper itself

Abstract

Metabolically unhealthy obesity (MUO) is associated with increased inflammation and a higher risk of metabolic disorders compared to metabolically healthy obesity (MHO). T cell dysregulation in blood and adipose tissue may contribute to obesity-induced metabolic dysfunction, yet the characteristics of T cell subset profiles and T-cell receptor (TCR) repertoires in MHO and MUO remain unclear. We analyzed T cell subsets and TCR repertoires in peripheral blood and omental adipose tissue (oAT) from age- and BMI-matched MHO and MUO individuals using flow cytometry and high-throughput TCR sequencing. MUO individuals exhibited a higher proportion of memory CD4

Indexed as

ObesityReceptors, Antigen, T-CellT-Lymphocyte SubsetsAdipose TissueAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHumansMaleMiddle AgedReceptors, Antigen, T-Celladipose tissuemetabolically healthy obesity (MHO)metabolically unhealthy obesity (MUO)obesityT cellTCR repertoire

Identifiers

PMID40244276
PMCPMC11989847

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.