Evidence map›Paper›PMID 40244262›Full record

ArticleInternational journal of molecular sciences2025

A Sex-Specific Minimal CpG-Based Model for Biological Aging Using

José Santiago Ibáñez-Cabellos, Juan Sandoval, Federico V Pallardó, José Luis García-Giménez, Salvador Mena-Molla

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

José Santiago Ibáñez-CabellosDepartment of Physiology, Faculty of Pharmacy, University of Valencia, 46100 Burjassot, Spain.ORCID 0000-0002-2462-653X
Juan SandovalHealth Research Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain.
Federico V PallardóDepartment of Physiology, Medicine and Dentistry School, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0003-3715-1980
José Luis García-GiménezDepartment of Physiology, Medicine and Dentistry School, University of Valencia, 46010 Valencia, Spain.ORCID 0000-0001-7547-7872
Salvador Mena-MollaDepartment of Physiology, Faculty of Pharmacy, University of Valencia, 46100 Burjassot, Spain.ORCID 0000-0002-6423-4741

Funding

Instituto Valenciano de Competitividad Empresarial (IVACE) Generalitat Valenciana through CREATEC-CV program IMCBTA/2018/29
6 · The paper itself

Abstract

Significant deviations between chronological and biological age can signal the early risk of chronic diseases, driving the need for tools that accurately determine biological age. While DNA methylation-based clocks have demonstrated strong predictive power for biological aging determination, their clinical application is limited by several barriers including high costs, the need to analyze hundreds of methylation sites using sophisticated platforms and the lack of standardized measurement tools and protocols. In this study, we developed a multivariate linear model using the analysis of eight CpGs within the promoter region of the very long chain fatty acid elongase 2 gene (

Indexed as

AgingCpG IslandsDNA MethylationFatty Acid ElongasesAdultAgedFemaleHumansMaleMiddle AgedPromoter Regions, GeneticSex CharacteristicsSex FactorsELOVL2 protein, humanFatty Acid Elongasesagingbiological ageDNA methylationepigenetic clocksepigenetics

Identifiers

PMID40244262
PMCPMC11989821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.