The Clinical Outcomes Among Patients Under 60 Years Old with Lynch Syndrome: Variations Based on Different Mutation Patterns.

Calin Muntean, Vasile Gaborean, Razvan Constantin Vonica, Alaviana Monique Faur, Vladut Iosif Rus, Ionut Flaviu Faur, Catalin Vladut Ionut Feier

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Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Calin MunteanMedical Informatics and Biostatistics, Department III-Functional Sciences, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.ORCID 0000-0002-0497-0405

Vasile GaboreanThoracic Surgery Research Center, "Victor Babeş" University of Medicine and Pharmacy Timişoara, Eftimie Murgu Square No. 2, 300041 Timişoara, Romania.ORCID 0009-0000-8647-1003

Razvan Constantin VonicaPreclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.

Alaviana Monique FaurFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania.

Vladut Iosif RusFaculty of Medicine, "Victor Babeş" University of Medicine and Pharmacy Timişoara, 300041 Timişoara, Romania.

Ionut Flaviu FaurIInd Surgery Clinic, Timisoara Emergency County Hospital, 300723 Timisoara, Romania.

Catalin Vladut Ionut FeierAbdominal Surgery and Phlebology Research Center, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.ORCID 0000-0002-3277-1198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lynch syndrome (LS)-also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC)-is caused by pathogenic germline mutations in DNA mismatch repair (MMR) genes such as

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisMutationAdultDNA Mismatch RepairGerm-Line MutationHumansMicrosatellite InstabilityMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinPrognosisMismatch Repair Endonuclease PMS2MLH1 protein, humanMSH2 protein, humanMutL Protein Homolog 1MutS Homolog 2 ProteinPMS2 protein, humanhereditary colorectal cancerLynch syndromemicrosatellite instabilitymismatch repair genesyoung-onset CRC

Identifiers

PMID40244260

DOI10.3390/ijms26073383

PMCPMC11990049

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